MAOA-uVNTR多态性与儿童早期问题行为之间的关系  

Relationship between MAOA-uVNTR Polymorphism and Young Children's Behavioral Problems

作　　者：刘亚鹏[1] 汪志鹏[1,2] 张明浩[1,3] 陈平[1] 张光珍[1] 梁宗保[1] 邓慧华[1] 陆祖宏[1,2] 

机构地区：[1]东南大学学习科学研究中心,南京210096 [2]东南大学生物医学工程学院,南京210096 [3]鲁东大学心理学院,烟台264000

出　　处：《中国临床心理学杂志》2014年第3期398-401,397,共5页Chinese Journal of Clinical Psychology

基　　金：教育部科技创新工程重大项目基金(704025);江苏省普通高校研究生科研创新计划项目(CXLX13_115);中央高校基本科研业务费专项资金的资助

摘　　要：目的:探讨MAOA-uVNTR多态性与儿童早期问题行为间的关系是否因年龄和性别而异。方法:在24和36个月时,采用婴幼儿社会情绪量表测量202名儿童的问题行为。通过PCR扩增技术和琼脂糖凝胶电泳检测技术分析所采集的口腔脱落细胞的基因多态性。结果:①24个月时,3型男孩比4型男孩表现更多违抗,但在同伴攻击、焦虑/抑郁和抑制/退缩上无差异;36个月时,MAOA基因对男孩违抗的影响只达到边缘显著水平。②24个月时,3/3和3/4型女孩表现更多同伴攻击,但在违抗、抑郁/焦虑和抑制/退缩上无差异;36个月时,4/4型女孩在抑制/退缩上的水平较高。结论:MAOA-uVNTR多态性对男孩违抗和女孩同伴攻击的影响随着年龄的增长而降低,但对女孩的抑制/退缩的影响随着年龄的增长而增加。Objective This study aimed to investigate the gender differences of dynamic effect of MAOA-uVNTR poly-morphism on behavioral problems in 202 young children. Methods： The cheek cells of children were collected when theyaged 6 months, and their behavioral problems were reported by their mothers at their 24-and 36-month age. The MAOA-uVNTR polymorphism was genotyped by a PCR technique. Results： Boys with 3R genotypes showed significantly higherdefense scores than boys with 4R genotypes at their 24-month age, but did marginally and significantly higher at their 36-month age. Girls with 3/3 and 3/4 genotypes showed significantly higher peer aggression than girls with 4/4 genotypes attheir 24-month age, but did significantly lower inhibition/social withdrawal at their 36-month age. Conclusion： The effectof MAOA-uVNTR polymorphism on boys＇ defense and girls＇ peer aggression becomes weaker with age, and on girls＇ inhi-bition/social withdrawal becomes stronger with age.

关 键 词：MAOA—uVNTR多态性 同伴攻击 违抗 抑郁 焦虑 抑制 退缩 

分 类 号：R395.1[哲学宗教—心理学]