血必净注射液对创伤性凝血病患者凝血功能及微循环灌注的影响  

The effect of Xuebijing Injection on coagulation function and microcirculation perfusion in patients with traumatic coagulopathy

作　　者：马明远[1] 江皓波[1] 徐杰[1] 张云海[1] 于娜[1] 黄国敏[1] 

机构地区：[1]广东省佛山市中医院重症医学科,528000

出　　处：《实用医学杂志》2014年第12期1993-1995,共3页The Journal of Practical Medicine

基　　金：广东省佛山市科研立项(编号:201208077)

摘　　要：目的:探讨血必净注射液对创伤性凝血病患者的凝血功能及微循环灌注的影响。方法:共98例患者纳入研究,随机分为治疗组(42例)和对照组(56例)。对照组接受常规治疗,治疗组在此基础上加用血必净注射液。检测两组患者不同时间点的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、D-二聚体(DD)、动脉血乳酸值(Lac),统计血制品使用量、多脏器功能不全(MODS)及血栓事件发生率、病死率并进行比较。结果:治疗前后比较,两组患者的PT、APTT、Lac治疗后均明显降低。组间比较,治疗组治疗12、18 h的Lac值及治疗48 h的APTT和DD、治疗72 h的PT、APTT和DD值均低于对照组。治疗组红细胞输注量、MODS及血栓事件发生率均明显低于对照组。结论:血必净注射液可改善患者PT和APTT、Lac水平,减少血栓事件的发生。Objective To study effect of Xuebijing injection on coagulation function and microcirculation perfusion in traumatic coagulopathy patients. Methods A total of 98 patients were randomly divided into Xuebijing Group （42 cases） and Control Group （56 cases）. Xuebijing group received Xuebijing injection, besides the regular treatment received by control group. PT, APTT, DD and Lac at different time points, transfusion amount, MODS incidence, thrombosis incidence, and mortality between two groups were compared. Result In Xuebijing Group, Lac at 12 h, 18 h; APTT, DD at 48 h; PT, APTT, DD at 72 h; Red Blood Cell transfusion, MODS incidence, and thrombosis incidence were significantly lower. Conclusion Xuebijing injection could improve PT, APTT, Lae, and decrease thrombosis incidence in traumatic coagulopathy patients.

关 键 词：创伤性凝血病 血必净注射液 凝血功能 微循环 

分 类 号：R641[医药卫生—外科学]