高血压患者动态动脉硬化指数与左心室质量指数、左心房内径的相关性分析  

Relationship Between the Ambulatory Arterial Stiffness Index and Left Ventricular Mass Index, Left Atrial Diameter in Patients With Hypertension

作　　者：陆玉琴[1] 李应东[2] 赵信科[1] 

机构地区：[1]甘肃中医学院附属医院心血管科,甘肃省兰州市730020 [2]甘肃中医学院

出　　处：《中国循环杂志》2014年第6期440-443,共4页Chinese Circulation Journal

摘　　要：目的:探讨高血压患者动态动脉硬化指数(AASI)、相应对称性动态动脉硬化指数(AASI-BPVR)与左心室质量指数(LVMI)、左心房内径(LAD)的相关性。方法:采用常规24 h动态血压监测数据测定及计算286例高血压病患者AASI、AASI-BPVR以及经超声心动图测定左心室舒张末内径、室间隔厚度、左心室后壁厚度、LAD,计算左心室质量、LVMI、相对室壁厚度,同时检测空腹血糖、血脂水平,进行Pearson相关分析及多元线性回归分析。将24 h AASI>中位数(即>0.51)者为A组(n=133),24 hAASI<中位数(即≤0.51)者为B组(n=153)。结果:A组较B组LVMI增加,差异有统计学意义(P<0.05),左心室质量虽较大,但差异无统计学意义(P=0.384);经Pearson相关分析,LVMI、LAD与各动态动脉硬化指数无明显相关,其中24 h AASI-BPVR与LAD相关系数r=0.111,但差异无统计学意义(P=0.057)。结论:AASI、AASI-BPVR不是高血压左心室肥厚及左心房扩大的独立影响因素,目前尚不能作为高血压心脏损害的预测因子。Objective： To explore the relationship between ambulatory arterial stiffness indexes （AAS1）, AASI-blood pressure variability （AASI-BPVR） and left ventrieular mass index （LVMI） left atrium diameter （LAD） in patients with hypertension. Methods： A total of 286 hypertensive patients were enrolled in this study. The AASI, AAS1-BPVR were calculated from 24-hour ambulatory blood pressure monitoring. Left ventricular internal dimension in diastole （LVIDd）, interventricular septal thickness in diastole （IVSd）, posterior wall thickness in diastole （PWd）, LAD were detected by echocardiograpby and LVM1, relative wall thickness （RWT） were calculated. The fasting blood glucose, blood lipids were examined. According to 24 h AASI, the patients were divided into 2 groups, Group A, the patients with AASI 〉 0.51, n=133 and Group B, the patients with AASI 〈 0.51, n=153. Pearson and multi regression analysis were conducted to analyze the relevant correlations. Results： Group A had increased LVMI than that in Group B, P〈0.05, the left ventricular masses were similar between 2 groups, P=0.384. Pearson correlation analysis indicated that LVMI and LAD were not related to arterial stiffness index, the coefficient between 24 h-AASI and LAD was at t=0.111, P=0.057. Conclusion： AASI and AASI-BPVR were not the independent factors for left ventricular hypertrophy and left atrial enlargement, therefore, they were not the predictors for cardiac damage in patients with hypertension at present time.

关 键 词：高血压 动脉硬化指数 左心室质量 左心房内径 

分 类 号：R541[医药卫生—心血管疾病]