通阳利湿方对神经根型颈椎病急性期模型大鼠的影响  

Effect of Tongyang Lishi Formula on Rats with Cervical Spondylotic Radiculopathy at Acute Stage

作　　者：王鹏[1] 乔钢 贾露露[3] 国延军[1] 牟成林[1] 赵建[1] 崔书国[1] 杜景华[1] 

机构地区：[1]河北省中医院骨伤科,石家庄050011 [2]河北省体育科学研究所门诊部,石家庄050011 [3]河北省石家庄市第一医院疼痛科,石家庄050011

出　　处：《河北中医药学报》2014年第2期1-3,共3页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北省中医药管理局资助项目:No 2012033

摘　　要：目的:探讨通阳利湿方对大鼠颈神经根急性疼痛的影响。方法:首先采用椎管插线法建立神经根型颈椎病急性根性疼痛大鼠模型。将符合入组条件的大鼠随机分成对照组与治疗组2组,每组20只。术后第5天、第20天分别对大鼠自发痛、步态评分、痛阈、游泳时间进行统计。结果:通阳利湿方能显著改善模型大鼠根性疼痛的相关行为,与对照组相比差异有显著性(P<0.05)。结论:通阳利湿方能明显减轻大鼠模型颈神经根急性根性疼痛,且提示有量效关系。Objective： to explore the effect of Tongyang Lishi formula on the acute pain of cervical spondylotic radiculopathy. Methods ： Model rats with acute cervical spondylotic radiculopathy were made through patching in spinal canal. The proper rats were divided into control group and treatment group, 20 rats in either group. The spontanecus pain, gait score, pain threshold and swimming time were statistically analyzed on the 5th and 20th day after the operation. Results ： The formula could remarkably improve the behavior related to mot pain. The difference between both group was significant （ P 〈 0. 05 ） . Conclusion ： Tongyang Lishi formula can significandy relieve the acute pain by cervical spondylotic radiculopathy, which suggests their dose-effect relationship.

关 键 词：关键词通阳利湿方 湿阻阳遏 神经根型颈椎病 自发痛 步态评分 痛阈 游泳时间 

分 类 号：R285.5[医药卫生—中药学]