2型糖尿病患者血清胱抑素C与冠状动脉狭窄的关系  

Relationship between serum cystatin C and coronary stenosis in type 2 diabetes mellitus patients

作　　者：王曼曼[1] 舒冏[1] 穆攀伟[1] 陈宣蓉[1] 陈燕铭[1] 曾龙驿[1] 

机构地区：[1]中山大学附属第三医院内分泌科,广东广州510630

出　　处：《中国民康医学》2014年第9期1-2,共2页Medical Journal of Chinese People’s Health

基　　金：广东省自然科学基金项目S2013010011533

摘　　要：目的:探讨2型糖尿病患者血清胱抑素C(CysC)与冠状动脉狭窄的关系。方法:2型糖尿病患者103例,根据320-DVCT中冠状动脉狭窄情况将患者分为两组:A组(n=35):无冠状动脉狭窄患者;B组(n=68):有冠状动脉狭窄患者(一支或多支冠脉狭窄),对比两组间血清CysC的差异。结果:患者血清CysC在A、B组分别是(0.73±0.39)mg/L,(1.25±0.62)mg/L,两组患者血清CysC水平有明显差异(P<0.05)。多元回归分析2型糖尿病合并冠状动脉狭窄的危险因素,血清CysC可作为一个独立的危险因素进入回归方程(P<0.05)。结论:2型糖尿病患者血清CysC与冠状动脉狭窄之间存在关联,可能可预测冠状动脉狭窄的风险。Objective：To investigate relationship between serum cystatinC（CysC）and coronary stenosis in type 2 diabetes mellitus（T2DM）patients. Methods：According to the coronary stenosis measured by 320-DVCT,a total of 103 T2DM patients visited our department of endocrinology from 2010 to 2012 were divided into two groups：no coronary stenosis group（group A,n=35）,coronary stenosis group（with one or more brunches coronary stenosis,group B,n=68）. CysC were determined. Results：Serum CysC in A and B group were 0. 73±0. 39mg/ L and1. 25±0. 62mg/ L,and there was a significant difference between the two groups（P﹤0. 05）. It was suggested that CysC was an independent risk factor of the progression to coronary stenosis in T2DM patients（P﹤0. 05）. Conclu-sions：There is a significantly positive correlation between CysC and coronary stenosis in T2DM patients. Serum CysC might be a predictor for coronary stenosis.

关 键 词：2型糖尿病 血清胱抑素C 320-DVCT 

分 类 号：R541.4[医药卫生—心血管疾病]