Graves病患者血清IL-17的表达  

Expression of serum IL-17 in GD patients

作　　者：李丽[1] 刘一鸣[1] 陈桐生[1] 何伟波[1] 李健[1] 

机构地区：[1]广东药学院附属第一医院核医学科,广东广州510080

出　　处：《广东药学院学报》2014年第3期363-365,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的检测Graves病(Graves disease,GD)患者血清IL-17水平,探讨IL-17在GD中的变化及意义。方法 148例GD患者分为3组:GD未治疗组(A组,70例)、131I治疗后GD控制组(B组,41例)和GD未控制组(C组,37例),另取32例健康体检者为正常对照组。酶联免疫法检测血清IL-17,电化学发光法检测FT3、FT4、TSH、TRAb。结果 GD患者的血清IL-17高于正常对照组(P<0.01);分组比较:IL-17在A组最高,C组次之,均高于正常对照组(P<0.01),B组最低,稍高于正常对照组,但差异无统计学意义(P>0.05);相关分析表明,GD患者血清IL-17的表达水平与FT3、FT4、TRAb的浓度呈正相关,与TSH浓度呈负相关(均为P<0.05)。结论 IL-17可能在GD的发病中起到重要作用,GD患者血清中FT3、FT4激素分泌增加可能与IL-17的高表达有关。Objective To investigate the level of serum IL-17 in Graves disease （GD） patients. Methods 148 patients with GD and 32 healthy controls were collected. All GD patients were further classified into three subgroups, including the GD-untreated group （ GroupA, n = 70） , the effective group （ GroupB, n = 41 ） and the non-effective group （ GroupC, n = 37 ） , Serum IL-17 level was assayed with ELISA. Free triiodothyronine （ FT3 ）, free thyroxine （ FT4）, thyrotropin （TSH） and thyrotropin receptor antibody （TRAb） were determined by electrochemiluminescence. Results The levels of serum IL-17 in all GD patients were significantly higher than those in the control group （P〈0.01）. The level of IL-17 in Group A was the highest, followed by Group B, and Group C was the lowest （P〈0.01）. Serum IL-17 was positively correlated with FT3, FT4 and TRAb levels （ P〈 0.05 ）, but negatively correlated with TSH （ P 〈 0.05 ）. Conclusion IL- 17 may play a vital role in the development of GD. Thyroid hormones in GD patients are closely correlated with the serum IL-17 level.

关 键 词：GRAVES病 131^I治疗 IL-17 

分 类 号：R581.1[医药卫生—内分泌]