麦冬提取物对妊娠期胰岛抵抗小鼠尿蛋白水平和脂联素表达的影响  

Effect of ophiopogonis- extract on the level of uric protein and the expression of adiponectin in mice with insulin resistance

作　　者：廖靖[1] 蔡东红[1] 符爱珍[1] 

机构地区：[1]广东医学院第一临床学院,广东湛江524023

出　　处：《药学研究》2014年第6期321-322,331,共3页Journal of Pharmaceutical Research

基　　金：湛江市科技计划项目(No.2010B030700014)

摘　　要：目的探讨麦冬提取物对妊娠期胰岛抵抗小鼠脂联素及尿蛋白水平的影响。方法取妊娠1周内的小鼠建立妊娠期胰岛抵抗小鼠模型。造模成功小鼠随机分为麦冬多糖125 mg·kg-1组、500 mg·kg-1组、模型组,每组各10只。另选10只正常妊娠小鼠,作为对照组。连续灌胃给药14 d后,观察其血糖及胰岛抵抗情况,并检测血清中的脂联素水平和尿蛋白的含量。结果与模型组小鼠相比,麦冬提取物各剂量组均可明显降低妊娠糖尿病小鼠的空腹血糖、改变胰岛素抵抗状况,升高血清中脂联素水平(P<0.05)。结论麦冬提取物有改善妊娠期小鼠胰岛素抵抗作用,并对预防妊高征的发生有一定的帮助。Objective To investigate the effect of ophiopogonis-extract on the level of Uric Protein and the expression of adiponectin in mice with insulin resistance. Methods The IR model was established by pregnancy mice in 1 week. Total of 40 model mice were randomly divided into ophiopogonis-extract 125 mg·kg-1 group,ophiopogonis-extract 500 mg·kg-1 group,model group. And 10 normal pregnancy mice were served as control group. Mice in control group and model control group were daily gavaged with NS for 14 d,and mice in ophiopogonis-extract 125 mg·kg-1 group and ophiopogonis-ex-tract 125 mg·kg-1 group were gavaged with ophiopogonis-extract 125 mg·kg-1 and 500 mg·kg-1 respectively for 14 d. The fasting blood glucose,serum insulin and uric protein were detected,the insulin resistance（ IR）was calculated,the ser-um adiponectin was determined by ELISA. Results The fasting blood glucose,serum insulin and uric protein were decrease in groups treated with ophiopogonis-extract compared with model group,but the level of APN expression in ophiopogonis-extract groups was higher than in model group. Conclusion Ophiopogonis-extract had definite protective effect,and could help to prevent PIH in pregnancy mice with insulin resistance.

关 键 词：麦冬 妊娠期 胰岛素抵抗 尿蛋白 脂联素 

分 类 号：R285.5[医药卫生—中药学]