24h动态血糖监测在妊娠期糖尿病患者中对妊娠结局的影响  

Effect of continuous glucose monitoring system to pregnancy outcome in gestational diabetes mellitus

作　　者：王娟[1] 陈学敬[1] 杨香菊[1] 陈柳华[1] 郭中秋[1] 王秀梅[2] 陈玉华[1] 

机构地区：[1]广东省深圳市龙岗区人民医院内分泌代谢科,广东深圳518172 [2]广东省深圳市龙岗区横岗人民医院妇产科,广东深圳518172

出　　处：《中国医药导报》2014年第16期143-145,153,共4页China Medical Herald

基　　金：广东省深圳市龙岗区科技计划医疗卫生项目(编号ys2012097)

摘　　要：目的探讨动态血糖监测系统（CGMS）对妊娠期糖尿病（GDM）患者妊娠结局的影响。方法选择2011年1月～2012年12月在深圳市龙岗区人民医院就诊的GDM患者60例，分为A组和B组，每组各30例。A组患者给予24h动态血糖监测，B组行常规末梢血糖检查，未予动态血糖监测。统计并比较：①两组孕妇妊娠高血压综合征、早产、宫内感染、羊水过多、胎膜早破、剖宫产等围生期并发症发生率；②两组新生儿高胆红素血症、低血糖、围生儿死亡、新生儿窒息、巨大儿的发生率及新生儿体重及新生儿胎龄情况。结果①B组妊娠高血压综合征[13．33％（4／30）]、早产[6．67％（2／30）]、宫内感染[6．67％（2／30）]、羊水过多[6．67％（2／30）]、胎膜早破[10．00％（3／30）]、剖宫产[53.33％（16／30）1发生率明显高于A组[6．67％（2／30）、3．33％（1／30）、0．00％（0／30）、0．00％（0／30）、3．33％（1／30）、40．00％（12／30）]，差异均有统计学意义（P〈0．05）。②两组围生儿并发症比较，B组高胆红素血症[13．33％（4／30）]、低血糖[6．67％（2／30）]、新生儿体重[（3345±512）g]、新生儿窒息[6．67％（2／30）]、巨大儿[6．67％（2／30）]等项均明显高于A组[6．67％（2／30）、0．00％（0／30）、（3045±460）g、0．00％（0／30）、0．00％（0／30）]，差异均有统计学意义（P〈0．05）。结论CGMS能为需要治疗的GDM患者提供早期的动态血糖监测，为后续的治疗提供更准确的血糖依据，是有效降低母婴并发症和合并症的监测方法之一。Objective To investigate the influence of pregnancy outcome in GDM patients by continuous glucose monitoring system （CGMS）. Methods 60 patients with GDM in Longgang District People＇s Hospital of Shenzhen City from January 2011 to December 2012 were selected and divided into group A and group B with 30 cases in each group. The group A was treated with continuous glucose monitoring for 24 h, group B was treated with normal peripheral blood sugar checking without continuous glucose monitoring. The indexes were observed and compared： ①the occurrence rate of perinatal complications of pregnancy induced hypertension, premature birth, intrauterine infection, polyhydramnios, premature rupture of fetal membranes, cesarean delivery in pregnant women of the two groups; ②the occurrence rate of hyperbilirubinemia, hypoglycemia, perinatal death, asphyxia neonatorum, fetal macrosomia, weight and gestational age in newborn of the two groups. Results ①The occurrence rate of pregnancy induced hypertension, pregnancy induced hypertension, intrauterine infection, polyhydramnios, premature rupture of fetal membranes, caesarean section in group B [13.33% （4/30）, 6.67% （2/30）, 6.67% （2/30）, 6.67% （2/30）, 10.00% （3/30）, 53.33% （16/30）] were all higher than those in group A [6.67% （2/30）, 3.33% （1/30）, 0.00% （0/30）, 0.00% （0/30）, 3.33% （1/30）, 40.00% （12/30）], the differences were statistically significant （P 〈 0.05）. ②The hyperbilirubinemia, hypoglycemia, newborn weight, neonatal asphyxia, fetal macrosomia in group B [13.33% （4/30）, 6.67% （2/30）, （3345±512） g, 6.67% （2/30）, 6.67%（2/30）] were all higher than those in group A [6.67% （2/30）, 0.00% （0/30）, （3045±460） g, 0.00% （0/30）, 0.00% （0/30）], the differences were statistically significant （P 〈 0.05）. Conclusion It is able for CGMS to provide the early dynamic blood sugar monitoring for GDM patients, it also can provide more accurate blood sugar basis for the subsequent

关 键 词：动态血糖监测 妊娠期糖尿病 妊娠结局 

分 类 号：R714.25[医药卫生—妇产科学]