输卵管妊娠介入治疗中血清孕酮、β-HCG值的预测价值  

Predictive value of serum progesterone and β-HCG in interventional treatment of tubal pregnancy

作　　者：张淑珍[1] 

机构地区：[1]浙江萧山医院,浙江杭州311200

出　　处：《中国医药导报》2014年第17期24-27,共4页China Medical Herald

摘　　要：目的探讨输卵管妊娠介入治疗中血清孕酮、人绒毛膜促性腺激素（β-CG）值的预测价值。方法选取2010年1月～2012年1月浙江萧山医院妇科住院患者120例为研究对象，根据治疗方法将其分为介入治疗组（40例）及保守治疗组（80例）。介入治疗组行经子宫动脉途径介入治疗，保守治疗组采用保守治疗。根据治疗效果将保守治疗组患者分为成功组（59例）与失败组（21例）。监测并比较各组治疗前后血清孕酮、血β-CG水平。结果介入治疗组停经时间为〉70-90d患者的术前血清β-CG、孕酮水平明显高于停经时间49～70d与〈49d的患者，差异有统计学意义（P〈0．05），而停经时间〈49d患者的血清β-HCG、孕酮水平与停经时间49～70d患者比较，差异无统计学意义（P〉0．05）。介入治疗组治疗成功率（92．50％）明显高于保守治疗组（73．75％），差异有统计学意义（P〈0．05）。随着血清β-HCG水平升高（〈10013、1000～2000、〉2000～5000、〉5000mU／mL），保守治疗组的治疗成功率逐渐下降（40．68％、32．20％、15．25％、11．86％），差异有统计学意义（P〈0．05）。成功组血清β-HCG、孕酮[（1129．35±273．16）mU／mL、（6．29±1．57）ng／mL]与失败组[（2613．29±3279．56）mU／mL、（10．82±1．95）ng／mL]比较，差异有统计学意义（P〈0．05）。血清β-CG和孕酮均为输卵管妊娠保守治疗成功的危险因素（OR=0．476、0．413，P=0．004、0．009）。结论血清孕酮、血β-CG均可作为输卵管妊娠介入治疗监测指标，在疗效监测中，血清孕酮较血β-HCG值更能早期预测疗效。Objective To explore the predictive value of serum progesterone and β-HCG in interventional treatment of tubal pregnancy. Methods 120 cases from January 2010 to January 2012 in Department of Gynecology in Zhejiang Xi- aoshan Hospital were selected as study objects, and they were divided into interventional treatment group （40 cases） and conservative treatment group （80 cases） according to the therapeutic methods. Patients of the interventional therapy group were treated with uterine artery interventional therapy, patients of the conservative treatment group were treated with conservative treatment, patients of the interventional therapy group were divided into success group （59 cases） and failure group （21 cases） according to the therapeutic effect. The level of progesterone and serum β-HCG preoperative of different groups before and after treatment were monitored and observed. Results In the interventional therapy group, the preoperative levels of serum β-HCG and progesterone in patients whose menopause time were 〉70-90 d were sig- nificantly higher than those of patients whose menopause time were 49-70 d and 〈49 d, the differences were statistical- ly significant （P 〈 0.05）, and the levels of serum β-HCG and progesterone between patients whose menopause time were 〈49 d and 49-70 d had no statistically significant difference （P 〉 0.05）. The treatment success rate of interventional treatment group （92.50%） was higher than that of conservative treatment group （73.75%）, the difference was statistically significant （P 〈 0.05）. With the increasing of serum β-HCG level （〈1000, 1000-2000, 〉2000-5000, 〉 5000 mIU/mL）, the lower of the treatment success rate, and the difference was statistically significant （P 〈 0.05）. The levels of serum β- HCG and progesterone in the conservative treatment success group were （1129.35±273.16） mU/mL, （6.29±1.57） ng/mL, and the failure group were （2613.29±3279.56） mU/mL, （10.82±1.95） ng/mL, the differ

关 键 词：血清孕酮 人绒毛膜促性腺激素 异位妊娠 介入治疗 疗效监测 

分 类 号：R714[医药卫生—妇产科学]