芦荟多糖对大鼠重型颅脑损伤继发高血糖的影响及机制  

The effect and mechanism of aloe polysaccharide on hyperglycemia induced by severe brain injury in rats

作　　者：叶俊[1] 磨洁琳[2] 于兰[3] 杨展[3] 陈敏[1] 

机构地区：[1]桂林医学院附属医院急诊科,广西桂林541001 [2]广西医科大学人体解剖学教研室,广西南宁530021 [3]桂林医学院人体解剖学教研室,广西桂林541004

出　　处：《华夏医学》2014年第1期9-12,共4页Acta Medicinae Sinica

基　　金：广西自然科学基金项目(2012GXNSFBA053110);广西卫生医疗重点科研项目(重2011012);广西高等学校资助科研项目(201203YB115)

摘　　要：目的:探讨芦荟多糖对大鼠重型颅脑损伤继发高血糖的影响及机制。方法:采用健康SD大鼠作实验材料,设对照组、假手术组、重型颅脑损伤模型组和芦荟多糖治疗组。采用自由落体撞击方法建立鼠重型颅脑损伤模型,治疗组给予芦荟多糖(150mg/kg体重)灌胃给药,其余3组给予等容量生理盐水,连续12d给药后检测血糖、胰岛素及胰高血糖素水平。结果:芦荟多糖治疗组血糖水平(6.15±0.76)mmol/L显著低于模型组(9.52±0.96)mmol/L,差异有统计学意义(P<0.05);芦荟多糖治疗组胰高血糖素水平(236.15±19.89)μg/ml显著低于模型组(319.52±27.16)μg/ml,差异有统计学意义(P<0.01);芦荟多糖治疗组胰岛素水平(5.92±1.66)mmol/L与模型组(6.02±2.02)mmol/L比较,差异无统计学意义(P>0.05)。结论:芦荟多糖对颅脑损伤继发高血糖有改善作用,其机制可能与降低了胰高血糖素水平有关。Objective：To investigate the effect and mechanism of aloe polysaccharide（AP） on hyper glycemia induced by sevcre brain injury（SBI） in rats. Methods： By using SD rats as experimental materials, SD rats were divided into control group, sham operation group, SBI model group and AP treatment group. SBI models were established by using free-fall impact. The treatment group was given AP（150 mg/kg body weight）administered intragastrically, and other 3 groups were given same volume of saline in same way. The levels of blood glucose, glucagon and insulin were measured 12 d after treatment. Results： The decreased levels of blood glucose occurred in AP treatment group（6.15.4±0.76）mmol/L, SBI model group（9.52±0.96）mmol/L, the difference was statistical ly significant（P〈0.05）. The glucagon level of AP treatment group （236. 15±19. 89）μg/ml was lower than that of the model group（319.52±27. 16）μg/ml and the difference was statistically sig nificant（P〈0.05）. There was no statistical difference in insulin levels between AP treatment group （5.92±1. 66）mmol/L and SBI model group（6. 02±2. 02）mmol/L（P〉0. 05）. Conclusion： AP could relieve the SBI induced for hyperglycemia to a certain extent, which may be associated with decreased glucagon levels.

关 键 词：重型颅脑损伤 高血糖 芦荟多糖 胰高血糖素 胰岛素 

分 类 号：R651.15[医药卫生—外科学]