中年男性Ⅱ型糖尿病患者基线血尿酸水平与冠状动脉病变的比较  

Prospective study between the baseline of serum uric acid level and coronary in middle-aged men with type Ⅱ diabetes

作　　者：麻秀娟[1] 郝凤杰[1] 焦秀华[1] 于桂芝[1] 王海丽[1] 

机构地区：[1]河北省承德市中心医院内分泌科,067000

出　　处：《心肺血管病杂志》2014年第3期333-336,共4页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:探讨中年男性Ⅱ型糖尿病患者基线血清尿酸(SUA)水平与冠状动脉病变程度的关系。方法:192例疑诊为急性冠状动脉综合征,并冠状动脉造影检查病变为阴性的中年男性患者,根据血糖分为糖尿病组及血糖正常组。5年后,再次发生急性冠状动脉综合征为终点事件并复查冠状动脉造影。应用冠状动脉狭窄指数(CSI)评价冠状动脉病变程度。结果:①糖尿病组与血糖正常组比较基线,SUA水平明显升高(P=0.028)、脂代谢紊乱尤以TC(P=0.012)、LDL-C(P=0.003)升高明显;CSI(P=0.001)、冠状动脉病变支数(P=0.000)及冠状动脉病变的确诊率(χ2=5.650,P=0.017)也明显增高。②经Spearman相关分析显示糖尿病组患者基线SUA水平与CSI、冠状动脉病变支数及冠状动脉病变患病率存在明显的相关性,相关系数分别为:r=0.474(P=0.001)、r=0.325(P=0.026)及r=0.301(P=0.040)。结论:中年男性Ⅱ型糖尿病患者基线SUA水平,与冠状动脉病变的发生发展存在着明显的相关性。Objective：To investigate the relationship between the baseline of serum uric acid and the severity of coronary artery disease （CAD） in middle-aged men with type 2 diabetes. Methods ： One hundred and ninety-two middle-aged men who were suspected acute coronary syndrome for the first time with negative coronarography were divided into 2 groups （ diabetes and normal blood glucose）, studied and followed-up for 5 years. The primary outcome was acute coronary syndrome suspected during 5 years of follow-up, and the coronarography was conducted at the same time. The severity of CAD was assessed by the coronary stenosis index （ CSI ）. Results： （j）The baseline of serum uric acid was higher in group of diabetes （ P 〈 0. 05 ） and the disorder of lipid metabolism was featured with high TC （P 〈 0. 05 ） and LDL-C （P 〈 0. 05 ） ; There were higher for CSI（P =0. 001 ） and coronary lesion vessels （P = 0. 000）, either the prevalence of CAD （X2 = 5. 650, P = 0. 017 ）. （2）The analysis of Spearman correlation showed that there was apparent relationship among the baseline level of serum uric acid with CSI and coronary lesion vessels, either the prevalence of CAD in the case diabetes. They were respectively for the correlation coefficients of different ： r = 0. 474 （ P = 0. 001 ） ,r = 0. 325 （ P = 0. 026）,r = 0. 301 （P = 0. 040）. Conclusion： The baseline level of serum uric acid was apparent relationship with the occurrence and development of CAD in middle-aged men with type 2 diabetes.

关 键 词：血清尿酸 冠状动脉病变 Ⅱ型糖尿病 前瞻性研究 

分 类 号：R541.4[医药卫生—心血管疾病]