超质量和肥胖急性冠状动脉综合征患者超敏C-反应蛋白水平与冠状动脉Gensini积分的关系  

Correlation between hs-CRP and Gensini score in patients suffering acute coronary syndrome with overweight and obesity

作　　者：肖冰[1] 罗太阳[1] 刘新民[1] 张崟[1] 刘小慧[1] 

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所心内科,100029

出　　处：《心肺血管病杂志》2014年第3期364-367,共4页Journal of Cardiovascular and Pulmonary Diseases

基　　金：国家自然科学基金(81170169)

摘　　要：目的:分析超质量和肥胖急性冠状动脉综合征(ACS)患者超敏C反应蛋白(hs-CRP)水平与冠状动脉病变复杂程度之间的关系。方法:入选2012年1月至2012年12月,于北京安贞医院行冠状动脉造影并确诊为ACS的患者304例,根据体质量指数(BMI)分为肥胖ACS组[BMI≥27(kg/m2)]84例、超质量ACS组[24≤BMI<27/(kg/m2)]133例,正常体质量ACS对照组[18.5≤BMI<24/(kg/m2)]87例。根据造影结果,按狭窄病变血管数分为单支病变及多支病变(2支病变以上);采用Gensini积分方法对冠状动脉狭窄程度进行定量评分,检测hs-CRP水平,分析hs-CRP与Gensini积分之间关系。结果:超质量和肥胖ACS患者hs-CRP水平显著高于对照组,超质量和肥胖ACS患者冠状动脉多支血管病变者较多,发生ACS的年龄较早;超质量和肥胖ACS患者hs-CRP水平与Gensini积分之间成显著正相关。结论:与正常体质量ACS患者相比,超质量及肥胖ACS患者的hs-CRP水平较高;血清hs-CRP水平与Gensini积分正相关,hs-CRP对于预测超质量和肥胖ACS患者冠状动脉病变复杂程度有一定价值,超质量及肥胖者应加强冠心病的一级预防。Objective： To investigate the levels of hs-CRP and correlation between hs-CRP and Gensini score in patients suffering acute coronary syndrome with overweight and obesity. Methods： A total of 304 patients with angiocardiography documented acute coronary syndrome were enrolled in Anzhen Hospital in 2012,84 patients of ACS with obesity, 133 patients of ACS with overweight and 87 patients of ACS with normal weight as control group were measured by body mass index. It was divided into the multi-vessel lesions group and the sin gle-vessel lesions group by the numbers of vessel according to the angiocardiography, Gensini score was used to evaluate the pathological change degree of coronary artery;the serum levels of hs-CRP were examined and analysed the relationship between hs-CRP and Gensini score. Results： Both the levels of hs-CRP in patients of ACS with obesity and overweight were higher than in control group, occurrence of multi-vessel lesions were more in study group than in control group,The ACS was earlier in obesity and overweight group than in control group; hs-CRP was positively correlated with the Gensini score in patients of ACS with obesity and in patients with. Conclusion ： Both the level of hs-CRP in patients of ACS with obesity and overweight were higher than in con-trol group;hs-CRP was positively correlated with the Gensini score the higher,the hs-CRP level has some value for indicating the complexity of coronary atherosclerosis for patients suffering acute coronary syndrome with overweight and obesity, overweight and obesity people should enhance the first prevention of CHD.

关 键 词：急性冠状动脉综合征 超质量 肥胖 超敏C反应蛋白 GENSINI积分 

分 类 号：R541.4[医药卫生—心血管疾病]