4875例新生儿高胆红素血症发病的危险因素及其影响  

Anlysis Risk Factors of Hyperbilirubinemia in 4875 Neonates

作　　者：赵捷[1] 杨勇[1] 梅家平[1] 杨传忠[1] 叶素芬[1] 钟慧君[1] 

机构地区：[1]南方医科大学附属深圳妇幼保健院新生儿科,深圳518000

出　　处：《中华妇幼临床医学杂志（电子版）》2014年第3期79-81,共3页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：目的分析新生儿高胆红素血症发病的危险因素及其影响。方法选择2009年1月至2012年12月本院普通新生儿病区12 975例住院治疗患儿中的4 875例高胆红素血症患儿为研究对象(本研究遵循的程序符合南方医科大学附属深圳妇幼保健院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与之签署临床研究知情同意书),并按照出生情况将其分为早产儿组(n=414)和足月儿组(n=4 461)。监测两组患儿经皮胆红素值(TCB)和血清总胆红素值(TSB)。结果本研究高胆红素血症发病率为37.6%(4 875/12 975)。新生儿高胆红素血症危险因素分别为围生期因素(48.5%)、感染因素(19.4%)、母乳性黄疸(17.2%)、ABO溶血病(10.2%)及其他因素(4.7%)。早产儿组和足月儿组上述各高胆红素血症发病危险因素比较,差异均有统计学意义(χ2=23.11,5.49,28.64,2.67,212.07;P<0.05)。结论早产儿相对足月儿易罹患高胆红素血症。对具有新生儿高胆红素血症危险因素的新生儿,尤其是早产儿,加强胆红素水平监测,并对TSB水平较高者及时实施干预措施,可有效降低胆红素脑部的发生率,改善其预后。Objective To analyze the risk factors of hyperbilirubinemia and the influence of them.Methods From January 2009 to December 2012,a total of 4 875 infants with hyperbilirubinemia which chosen from 12 975 newborn patients were included in the study.They were divided into preterm infant group（n=414） and full term infant group（n =4 461）.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shenzhen Maternity and Child Healthcare Hospital.Informed consent was obtained from each participants.Their transcutaneous bilirubin（TCB）and total serum bilirubin（TSB） were detected.Results The incidence rate of hyperbilirubinemia was 37.6% （4 875/12 975）.The perinatal factors（48.5%）,infection（19.4%）,breast jaundice（17.2%）,ABO hemolysis （10.2%） and other factors （4.7%） were the risk factors of hyperbilirubinemia.There had significant differences between two groups in these factors（χ^2 =23.11,5.49,28.64,2.67,212.07;P〈0.05）.Conclusions Compared with full term infamts,preterm infants have more chances to get hyperbilirubinemia.As far as possible to reduce the risk factors of hyperbilirubinemia,especially to strengthen the prevention of neonatal bilirubin encephalopathy.

关 键 词：婴儿 新生 高胆红素血症 危险因素 

分 类 号：R722.1[医药卫生—儿科]