纳洛酮与醒脑静治疗急性酒精中毒疗效比较的系统评价  

Naloxone and Xingnaojing in the treatment of acute alcohol intoxication:a systematic review

作　　者：徐桂中[1] 陈阵[1] 丰莉娟[1] 刘显灼 杨洋[1] 李维[1] 艾芬[1] 

机构地区：[1]湖北省武汉市中心医院急诊科,430014

出　　处：《职业与健康》2014年第11期1485-1489,共5页Occupation and Health

摘　　要：目的评价纳洛酮与醒脑静治疗急性酒精中毒的疗效。方法计算机检索英文数据库:PubMed、Science Direct、EBSCO Host、Embase、The Cochrane Library,中文数据库:中国知网、万方数据库、维普数据库,检索年限:1991年1月1日—2013年8月1日。收集纳洛酮与醒脑静治疗急性酒精中毒的随机对照试验(RCT),对纳入研究进行质量评价后,采用RevMan 5.0软件进行meta分析。结果共纳入10篇中文RCT均为低质量文献,meta分析结果显示:①纳洛酮与醒脑静治疗急性酒精中毒的有效率无明显差别[OR=0.65,95%CI(0.35,1.20),P=0.17,I2=75%];②纳洛酮治疗急性酒精中毒的清醒时间短于醒脑静[MD=-12.27,95%CI(-14.08,-10.45),P=0.24,I2=48%];③纳洛酮治疗急性酒精中毒症状消失时间短于醒脑静[MD=-10.65,95%CI(-14.87,-6.43),P=0.21,I2=36%]。结论纳洛酮治疗急性酒精中毒疗效优于醒脑静,可供一线临床急诊医生首选药物参考。[ Objective] To evaluate the curative effect of naloxone and Xingnaojing in the teatment of acute alcohol intoxication. [ Methods ] English databases such as PubMed, Science Direct, EBSCO Host, EMbase and the Cochrane Library and Chinese da- tabases such as CNKI, Wanfang and CQVIP were retrieved from Januaryl, 1991 to August 1,2013. The randomized controlled trials of naloxone and Xingnaojing in the treatment of acute alcohol intoxication were collected, the quality of the included studies were evaluated, and the RevMan 5.0 was adopted to carry out recta-analysis. [ Results ] 10 Chinese RCTs included were low quality literatures. The resuhs of meta-analysis showed that ： （1）the effective rate of naloxone and Xingnaojing in the treatment of acute alcohol intoxication had not significant difference [ OR = 0.65, 95% CI （ 0.35,1.20）, P = 0.17, 12 = 75% ] ; （2）The waking hours of naloxone in treatment of acute alcohol intoxication were shorter than that of Xingnaojing. [ MD = -12.27, 95% CI （ -14.08, -10.45 ）, P = 0.24, 12 = 48% ] ; （3）The symptom disappearance time of naloxone in treatment of acute alcohol intoxication were shorter than that of Xingnaojing. [ MD = -10.65, 95% CI （ -14.87, - 6.43 ）, P = 0.21, 12 = 36% ]. [ Conclusion] The curative effect of naloxone in treatment of acute alcohol intoxication is better than that of Xingnaojing. It can provide preferred drug reference for firstline clinical emergency physicians.

关 键 词：醒脑静 纳洛酮 酒精中毒 系统评价 

分 类 号：R181.32[医药卫生—流行病学]