FHL蛋白与肺动脉高压研究进展  

Development of FHL Protein and Pulmonary Hypertension

作　　者：李康[1] 戴爱国[1] 蒋永亮[1] 

机构地区：[1]南华大学附属省马王堆医院呼吸疾病研究所

出　　处：《现代生物医学进展》2014年第18期3581-3584,3588,共5页Progress in Modern Biomedicine

基　　金：湖南省中医药科研计划项目重点课题(2009007);国家自然基金科学基金面上项目(81270118)

摘　　要：FHL(four-and-a-half-LIM domain)是含4(1/2)个LIM结构域富含半胱氨酸的细胞骨架蛋白,LIM是一种在C.elegans线虫的Lin-1和Mec-3基因及大鼠Isl-1基因编码的DNA结合蛋白中分离鉴定出来的基因序列,LIM取三个基因的首字母而成。FHL家族含FHL-1-5五个成员,而FHL-1-3最早发现在心脏的发育过程中起重要作用,后面发现在肺动脉高压中有促进增殖、迁移等作用。本文就FHL家族和肺动脉高压关系作一综述,阐明FHL蛋白在PH进程中的重要作用。FHL（four-and-a-half-LIM domain） a cytoskeletal protein which containing 4（1/2） LIM domain and cysteine-rich, The name of the LIM domain, is derived from three homeodomain proteins（Caenorhabditis elegans Lin-11, rat Isl-1, and C. elegans Mec-3）. This domain has been recognized in a variety of cytoplasmic and nuclear functional molecules. FHL family including FHL-1-5 five members, and FHL-1-3 was discovered important effect in the development of the heart, the latter found that they can promote proliferation, migration and so on in the process of PH. This review aims to summarize the relathionship between FHL and PH.

关 键 词：FHL(four-and-a-half-LIM domain) LIM(Lin-Isl-Mec) 肺动脉高压 

分 类 号：R562[医药卫生—呼吸系统]