AECOPD患者血清降钙素原与其它炎症指标水平的相关性分析  

Analysis of the Correlations of Serum Procalcitonin Level with Other Inflammatory Markers in Patients with AECOPD

作　　者：吴长东[1] 张静[1] 梁玥[1] 刘政疆[1] 薛克栋[1] 

机构地区：[1]新疆维吾尔自治区人民医院,新疆乌鲁木齐830001

出　　处：《现代生物医学进展》2014年第19期3726-3728,共3页Progress in Modern Biomedicine

摘　　要：目的:分析慢性阻塞性肺疾病急性加重(AECOPD)患者血清降钙素原与其它炎症指标水平的相关性。方法:选择2012年1月至2012年12月我院重症医学科收治的195例AECOPD患者作为研究对象,所有患者均采血后行降钙素原(procalcitonin,PCT)、超敏C反应蛋白(C-reactive protein,hs-CRP)、血常规(blood General,WBC)、血沉(erythrocyte sedimentation rate,ESR)、白介素六(interleukin-6,IL-6)检测,同时采集痰标本后行痰培养和药敏试验检测,分析其血清PCT水平与其它炎症指标的相关性。结果:195例AECOPD患者中,PCT增高者43例(22.1%),正常者152例(77.9%),其血清PCT水平与hs-CRP、WBC、中性粒细胞百分比(neutrophil percentage,NEUT%)均显著相关(P<0.05),相关系数分别为0.262、0.382、0.333,与ESR、IL-6、痰培养结果无明显相关性(P>0.05)。结论:血清PCT水平判定AECOPD患者是否合并感染有一定的局限性,联合检测hs-CRP、WBC、NEUT%,可作为诊断AECOPD感染的有力补充。Objective： To analyze the correlations of serum procalcitonin level with other inflammatory markers in patients with AECOPD. Methods： 195 patients with AECOPD hospitalized from January 2012 to December 2012 in critical care medicine of our hospital were selected as research subjects, the serum procalcitonin （PCT）, high-sensitivity C-reactive protein （hs-CRP）, blood General, erythrocyte sedimentation rate （ESR）, interleukin-6 （IL-6） levels were detected, and the sputum samples were underwent sputum culture and sensitivity assay, the correlations between procalcitonin and other inflammatory markers were analyzed. Results： In 195 cases of AECOPD, PCT levels were increased in 43 cases （22.1%） and normal in 152 cases （77.9%）; PCT increased with The hs-CRP, WBC, neutrophil percentage （NEUT%） were significantly different between AECOPD patients with normal and heighten serum PCT levels （P〈0.05）. Positive correlations were found between serum PCT levels and hs-CRP, WBC, NEUT% of AECOPD patients（r=0.262, 0.382, 0.333, P〈0.05）. Conclusion： There were certain limitations of PCT in the determination of infection in patients with AECOPD, so combined detection ofhs-CRP, WBC, NEUT% could be used as complement.

关 键 词：慢性阻塞性肺疾病 降钙素原 超敏C反应蛋白 白介素-6 

分 类 号：R563.9[医药卫生—呼吸系统]