CysC,mALB和尿BGM联合检测在2型糖尿病早期肾损中的临床价值  

The Clinical Value of CysC, mALB and Urine BGM Combined Detection of Early Renal Damage in Type 2 Diabetes

作　　者：曹姬 郑贵星[2] 马海丹 刘灿华 郑晓芬 

机构地区：[1]深圳市龙华新区人民医院检验科,广东深圳518109 [2]广州医科大学附属第一医院输血科,广东广州510120 [3]深圳市龙华新区人民医院妇科,广东深圳518109 [4]深圳市龙华新区人民医院B超室,广东深圳518109 [5]深圳市龙华新区人民医院护理部,广东深圳518109

出　　处：《现代生物医学进展》2014年第21期4120-4122,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨CysC、mALB和尿BGM联合检测在2型糖尿病早期肾损中的临床价值。方法:选取2010年11月至2013年6月我院内分泌科收治的130名2型糠尿病患者,根据空腹血糖值的不同程度将其分为A、B两组,A组72例,B组58例,另选取同期在我院体检的年龄、性别等资料与之匹配的64名健康者设为C组。分别对其CysC、mALB和尿BGM进行测定,并进行对比分析。结果:通过分析可知,A组和B组的Cys C分别为(3.29±1.09)mg/L、(2.86±1.05)mg/L,相对于C组的(0.87±0.99)mg/L,均明显升高,但A组升高更加明显;A组、B组、C组的mALB分别为(37.36±4.82)mg/L、(36.55±4.31)mg/L、(6.61±3.84)mg/L,B组高于A组,C组高于A组和B组;三组的BGM中,以A组最高,为(634.15±55.24)μg/L,B组其次,为(626.92±48.18)μg/L,均高于C组的(57.12±11.75)μg/L;Cys C、mALB、BGM等阳性指标的检出率分别为76.15%、77.69%、72.31%,而Cys C、mALB、BGM联合检测的检出率为93.85%,明显高于其他单指标检测。且P<0.05,差异具有统计学意义。结论:对CysC、mALB和尿BGM进行联合检测对2型糖尿病早期肾损患者具有较高的检出率,相对于单指标检测,敏感性更高。Objective： To investigate the clinical value of CysC, mALB and urine BGM combined detection of early renal damage in type 2 diabetes. Methods： From November 2010 to June 2013, 130 patients with type 2 chaff in urine treated in Endocrinology Department of our hospital were selected and divided, according to different levels of fasting blood glucose values, into Group A and Group B, with 72 cases and 58 cases respectively. 64 healthy people who had physical examination in our hospital over the same period with similar age, sex and other data were selected as Group C. Respectively, of its CysC, mALB BGM and urine were measured and compared. Results： The analysis shows that, Cys C of Group A and of Group B was, respectively （3.29± 1.09） mg / L, （2.86± 1.05） mg / L, both increased more significantly than that of Group C （0.87± 0.99） mg / L, and more obvious in Group A; mALB of the three groups were （37.36±4.82） mg / L, （36.55± 4.31） mg / L, and （6.61±3.84） mg / L, group B than in group A, and highest in Group C; BGM in Group A was the highest （634.15＋ 55.24） μg / L, second in Group B （626.92± 48.18） μg / L, respectively, and lowest in Group C （57.12± 11.75） μg / L; Cys C, mALB, BGM and other positive indicators detection rates were respectively 76.15%, 77.69%, and 72.31%, while the Cys C, mALB, BGM joint detection rate was 93.85%, significantly higher than other single-index detection. And P〈0. 05, with statistically significant difference. Conclusion＂ Cys C, mALB and urine BGM joint detection of early renal damage in type 2 diabetes patients with high detection rate, as opposed to a single index detection sensitivity is higher.

关 键 词：半胱氨酸抑制酶C 尿微量清蛋白 尿Β2-微球蛋白 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]