脐带间充质干细胞辅助治疗难治性类风湿性关节炎的临床观察  

Clinical Observation on the Umbilical Cord Mesenchymal Stem Cells in the Adjuvant Treatment of Refractory Rheumatoid Arthritis

作　　者：杨华强[1,2] 李红[1] 胡明均[1] 李玉玲[1] 覃骏[1] 鲍红霞[1] 吕晓娟[1] 

机构地区：[1]湖北医药学院附属人民医院血液科,湖北十堰442000 [2]湖北医药学院附属太和医院细胞治疗中心,湖北十堰442000

出　　处：《现代生物医学进展》2014年第21期4137-4139,共3页Progress in Modern Biomedicine

摘　　要：目的：观察脐带间充质干细胞辅助治疗难治性类风湿性关节炎的疗效和安全性。方法：将细胞总数为（5～7）× 107 个脐带间充质干细胞通过静脉输注途径移植到自愿接受干细胞移植的2 例难治性类风湿性关节炎患者体内，4 次为1 个疗程，每次间隔1周。治疗后随访1 年定期观察患者临床症状及各项生化和免疫学指标的变化并进行综合分析。结果：脐带间充质干细胞辅助治疗后1 月余，2 例患者的临床症状明显改善，28 个关节的疾病活动度评分（DAS-28）由3.6 和4.0 分别降低为2.2 和2.6，血沉、C 反应蛋白水平和类风湿因子抗体滴度也较治疗前明显降低。随访1 年余未观察到与治疗有关的副作用，并且症状持续缓解无复发。结论：脐带间充质干细胞辅助治疗可缓解难治性类风湿性关节炎的临床症状，且未观察到与治疗有关的副作用，安全性好，值得临床进一步研究其远期疗效。Objective： To observe the clinical effect and safety of UC-MSC （umbilical cord mesenchymal stem cells, UC-MSC） transplantation in the adjuvant treatment of refractory rheumatoid arthritis. Methods： Two patients with refractory rheumatoid arthritis were received UC-MSC transplantation （4 times as a course of treatment which every time interval one week ） with total cellular number of UC-MSC was 5～7× 10^7 by intravenous infusion. Both patients were followed up regularly for one year after transplantation. Clinical symptoms and various biochemical and immunological index were observed and literature review was performed. Results： After trans- plantation, the clinical symptoms of both patients improved obviously. After transplantation, DAS-28 score of 28 arthrosis of 2 patients decreased from 3.6 and 4.0 to 2.2 and 2.6 respectively. There were significant reduction in ESR, CRP level and RA antibody titer at 1 months after transplantation than those pre-treatment. No significant difference was observed when compared post-treatment with pre-treatment of biochemical parameters, which contains blood routine, hepatic function, renal ruction, serum immunoglobulin, complement C3/C4. Both patient＇s condition was continously catabatic and no recurrence was found after one year was followed up. Conclusion： The UC-MSC transplantation could ameliorate clinical manifestations and delay progression of rheumatoid arthritis. It was convenient, safe and effective in the treatment of refractory rheumatoid arthritis, but further observation was still required to evaluate its long term efficacy.

关 键 词：干细胞移植 难治性类风湿性关节炎 治疗 脐带间充质干细胞 

分 类 号：R593.22[医药卫生—内科学]