Tumor-suppressor effects of chemical functional groups in an in vitro co-culture system  

作　　者：Su-Ju xu Fu-Zhai CUI Xiang-Dong KONG 

机构地区：[1]Institute of Biomaterials and Marine Biological Resources, College of Life Sciences, Zhejiang Sci-Tech University Hangzhou 310018, China [2]Institute of Regenerative Medicine and Biomimetic Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China

出　　处：《Frontiers of Materials Science》2014年第2期136-141,共6页材料学前沿（英文版）

基　　金：Acknowledgements This work was in part supported by the National Basic Research Program of China （Grant No. 2011 CB606205）, the National Natural Science Foundation of China （Grant No. 51272236）, and the Program for 521 Excellent Talents ofZhejiang Sci-Tech University.

摘　　要：Liver normal cells and cancer cells co-cultured on surfaces modified by different chemical functional groups, including mercapto （-SH）, hydroxyl （-OH） and methyl （-CHz） groups. The results showed that different cells exhibited changes in response to different surfaces. Normal cells on -SH surface exhibited the smallest contact area with mostly rounded morphology, which led to the death of cancer cells, while cancer cells could not grow on -CH3 groups, which also died. In the co-culture system, the -CH3 group exhibited its unique effect that could trigger the death of cancer cells and had no effects on normal cells. Our findings provide useful information on strategies for the design of efficient and safe regenerative medicine materials.Liver normal cells and cancer cells co-cultured on surfaces modified by different chemical functional groups, including mercapto （-SH）, hydroxyl （-OH） and methyl （-CHz） groups. The results showed that different cells exhibited changes in response to different surfaces. Normal cells on -SH surface exhibited the smallest contact area with mostly rounded morphology, which led to the death of cancer cells, while cancer cells could not grow on -CH3 groups, which also died. In the co-culture system, the -CH3 group exhibited its unique effect that could trigger the death of cancer cells and had no effects on normal cells. Our findings provide useful information on strategies for the design of efficient and safe regenerative medicine materials.

关 键 词：tumor suppressor chemical functional group co-culture system regen-erative medicine material 

分 类 号：Q813.11[生物学—生物工程] S791.270.1[农业科学—林木遗传育种]