Modification of polycarbonateurethane surface with poly （ethylene glycol） monoacrylate and phosphorylcholine glyceraldehyde for anti-platelet adhesion  

作　　者：Jing YANG Juan LV Bin GAO Li ZHANG Dazhi YANG Changcan SHI Jintang GUO Wenzhong LI Yakai FENG 

机构地区：[1]School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China [2]Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Tianjin 300072, China [3]Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University, Tianjin 300072, China [4]University of Rostock, Department of Cardiac Surgery, Reference & Translation Center for Cardiac Stem Cell Therapy, Schillingallee 69, D-18057 Rostock, Germany

出　　处：《Frontiers of Chemical Science and Engineering》2014年第2期188-196,共9页化学科学与工程前沿（英文版）

基　　金：Acknowledgements This work has been financially supported by Ministry of Science and Technology of China （Grants No. 2013DFG52040 and 2008DFA51170）, National Natural Science Foundation of China （Grant No. 31370969）, and Ph.D. PrograFns Foundation of Ministry of Education of China （No. 20120032110073）.

摘　　要：Poly（ethylene glycol） monoacrylate （PEGMA） is grafted onto polycarbonateurethane （PCU） surface via ultraviolet initiated photopolymerization. The hydroxyl groups of poly（PEGMA） on the surface react with one NCO group of isophorone diisocyanate （IPD1） and another NCO group of IPDI is then hydrolyzed to form amino terminal group, which is further grafted with phosphorylcholine glyceraldehyde to establish a biocompatible hydrophilic structure on the surface. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the successful grafting of both PEG and phosphorylcholine functional groups on the surface. The decrease of the water contact angle for the modified film is caused by synergic effect of PEG and phosphorylcholine, which both have the high hydrophilicity. Furthermore, the number of platelets adhered is relative low on the synergetically modified PCU film compared with the PCU film modified only by poly（PEGMA）. Our synergic modification method using both PEG and phosphorylcho- line may be applied in surface modification of bloodcontacting biomaterials and some relevant devices.Poly（ethylene glycol） monoacrylate （PEGMA） is grafted onto polycarbonateurethane （PCU） surface via ultraviolet initiated photopolymerization. The hydroxyl groups of poly（PEGMA） on the surface react with one NCO group of isophorone diisocyanate （IPD1） and another NCO group of IPDI is then hydrolyzed to form amino terminal group, which is further grafted with phosphorylcholine glyceraldehyde to establish a biocompatible hydrophilic structure on the surface. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the successful grafting of both PEG and phosphorylcholine functional groups on the surface. The decrease of the water contact angle for the modified film is caused by synergic effect of PEG and phosphorylcholine, which both have the high hydrophilicity. Furthermore, the number of platelets adhered is relative low on the synergetically modified PCU film compared with the PCU film modified only by poly（PEGMA）. Our synergic modification method using both PEG and phosphorylcho- line may be applied in surface modification of bloodcontacting biomaterials and some relevant devices.

关 键 词：poly（ethylene glycol） monoacrylate phos-phorylcholine polycarbonateurethane surface modifica-tion anti-platelet adhesion biomaterials 

分 类 号：TQ433.436[化学工程] S511.01[农业科学—作物学]