芪归银复方化学成分研究进展  

Research Progress in Chemical Constituents of Qi-Gui-Yin Compound

作　　者：于小杰[1] 张加余[2] 刘清泉[3] 刘永刚[1] 冯欣[1] 石航[1] 马群[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]北京中医药大学科研实验中心,北京100029 [3]北京中医医院,北京100010

出　　处：《世界科学技术-中医药现代化》2014年第5期1174-1181,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委青年基金项目(81102777):基于多肽阵列技术的芪归银方延缓耐药物质基础及作用机制研究;负责人:马群;科学技术部"重大新药创制"科技重大专项(2013ZX09102026):芪归银颗粒延缓/逆转多重耐药菌临床前研究;负责人:刘清泉;北京中医药大学研究生资助项目(5320100604292):芪归银血清中化学成分研究;负责人:于小杰

摘　　要：芪归银复方由黄芪、当归、金银花、青蒿、虎杖5味药组成,不仅能够配合抗生素治疗耐药菌,而且能延缓、甚至逆转细菌耐药性的产生,但是该复方化学成分复杂,尚未明确其治病的物质基础。因此,通过查阅文献,对该方中5种单味药中的化学成分进行总结,并对其中所含的170种化学成分进行归类,以期为芪归银复方中化学成分研究提供依据,最终明确其延缓耐药的物质基础。Qi-Gui-Yin （QGY） compound, which composes of five herbal medicines of Astragalus membranaceus （Fisch.） Bge., Angelica sinensis （Oliv.） Diels, Lonicera japonica Thunb., Artemisia annua L., and Polygonum cuspidatum Sieb.et Zucc., which is able to treat antibiotic-resistant bacteria with antibiotics, and also to delay or even reverse the bacterial resistance producing. However, QGY compound is a complex mixture. And it is very difficult to elaborate its material foundation. Therefore, chemical constituents in five herbal medicines were summarized through searching of the related literatures. And then, 170 kinds of bioactive ingredients were classi-fied in order to provide evidences for the study on chemical constituent of QGY compound and identify its mate-rial foundation of delaying drug resistance .

关 键 词：芪归银复方 延缓耐药 物质基础 研究进展 

分 类 号：R284[医药卫生—中药学]