急性缺氧对健康人三尖瓣返流的影响  

Effect of acute hypoxia on tricuspid regurgitation

作　　者：李双菲[1] 武晓静[1] 杨特[1] 李相俊[1] 覃军[1] 刘曦[1] 黄岚[1] 

机构地区：[1]第三军医大学新桥医院、全军心血管病研究所,重庆400037

出　　处：《军事医学》2014年第4期245-247,251,共4页Military Medical Sciences

基　　金：国家卫计委卫生行业科研专项基金资助项目(201002012);国家自然科学基金资助项目(81270109)

摘　　要：目的：研究急性缺氧和短期缺氧适应对三尖瓣返流的影响。方法从2012年5～9月共入选176例健康青年男性。利用彩色超声多普勒技术采集急性缺氧（氧浓度12％）前后三尖瓣返流的相关参数（返流面积、返流压差、最大返流速度），分析急性缺氧前后三尖瓣返流发生和缓解的情况。结果与常氧组相比，急性缺氧组三尖瓣返流率（76％vs 48％）、返流压差（25．65 mmHg vs 19．33 mmHg）、最大返流速度（251．38 cm/s vs 220．62 cm/s）明显升高，而返流面积无明显差异。与急性缺氧组相比，缺氧2周组三尖瓣返流率（50％vs 76％）、返流压差（20．83 mmHg vs 25．65 mmHg）、最大返流速度（225．69 cm/s vs 251．38cm/s）明显下降，而返流面积则无明显差异。结论急性缺氧促进并加重三尖瓣返流，而短期的缺氧适应可以逆转该过程。Objective To explore the effect of acute hypoxia on tricuspid regurgitation .Methods 176 healthy young males were selected and their tricuspid regurgitation parameters in normoxia and after acute exposure to hypoxia （ oxygen concentrations 12%） were collected by color Doppler technology .The conditions of tricuspid regurgitation were compared between the two groups .Results Tricuspid regurgitation was significantly increased after the subjects were exposed to hypoxia.Tricuspid regurgitation rate （76% vs 48%）, regurgitation pressure （25.65 mmHg vs 19.33 mmHg） and maxi-mum regurgitation velocity （251.38 cm/s vs 220.62 cm/s） were higher in the hypoxia group .However, there was no significant change in the regurgitation area .After two weeks of adaptation to hypoxia , the tricuspid regurgitation rate （50%vs 76%）, regurgitation pressure （20.83 mmHg vs 25.65 mmHg） and maximum regurgitation velocity （225.69 cm/s vs 251.38 cm/s） significantly decreased and returned to the level before hypoxic exposure .Conclusion Acute hypoxic expo-sure can induce and aggravate tricuspid regurgitation ,and short-term adaptation to hypoxia can reverse the trend .

关 键 词：三尖瓣返流 缺氧 高原 

分 类 号：R541[医药卫生—心血管疾病]