高原暴露健康青年人群心室肌复极变化研究  

Change in ventricular repolarization among healthy young males exposed to high altitude

作　　者：徐佰达[1] 卢巍[1] 余洁[1] 覃军[1] 张继航[1] 李双菲[1] 黄岚[1] 

机构地区：[1]第三军医大学新桥医院心内科、全军心血管病研究所,重庆400037

出　　处：《军事医学》2014年第4期259-261,280,共4页Military Medical Sciences

基　　金：国家卫计委卫生行业科研专项基金资助项目(201002012)

摘　　要：目的探讨高原暴露在不同海拔及不同习服时间的健康青年男性心室肌复极的变化规律。方法随机选择143名初次进入高原的健康青年男性,由同一人分测在海拔500 m、进入海拔3700 m高原24 h、海拔4400 m习服7 d、海拔4400 m习服50 d心电图的变化。结果与海拔500 m比较,进入海拔3700 m 24 h内、海拔4400 m习服7 d,心率、收缩压,舒张压显著升高(P<0.01),经心率校正的QT间期(QTc)、经心率校正的T波峰末间期(TpTec)显著延长(P<0.05),氧饱和度显著降低(P<0.05),QT间期、T波峰末间期(TpTe)显著缩短(P<0.05)。与海拔500 m比,海拔4400 m习服50 d后,氧饱和显著降低(P<0.05),仍未恢复到平原水平,收缩压、舒张压、QTc、QT、V3TpTe、V3TpTec间期无明显差异(P>0.05)。结论急性高原暴露健康青年男性心室肌复极时程显著增加,习服后心室肌复极时程又逐渐恢复到平原水平,提示随着高原环境停留时间的延长,心室肌复极变化会随着机体适应和调节得到一定的恢复。Objective To investigate the change in ventricular repolarization at different altitudes and time courses among healthy young males .Methods A total of 143 healthy young men living on the plains were randomly selected as subjects.Their change in relative parameters of ventricular repolarization was measured by the same person at 500 m above sea level,24 hours their ascent to the plateau at an altitude of 3700 m was,after one week′s acclimatization on the 4400 m plateau and after 50 days acclimatization on the 4400 m plateau.Results Compared with 500 m,at 3700 m above sea level in 24 hours and after one week′s acclimatization on the 4400 m plateau,the heart rate（HR）,systolic blood pressure（SBP）, diastolic blood pressure（DBP）, heart rate-corrected-QT （QTc）interval and heart rate-corrected T-peak to T-end （TpTec） on V3 lead were significantly increased（P〈0.05）.while oxygen saturation, QT interval,T-peak toT-end（TpTe）interval on V3 lead were significantly decreased （ P〈0.05） .Compared with 500 m, oxygen saturation significantly decreased （ P〈0.05）,while SBP,DBP,QT interval,QTc interval,TpTe interval,TpTec interval did not change significantly （P〉0.05） after 50 days acclimatization on the 4400 m plateau.Conclusion The ventricular repolarization duration of these young healthy men was significantly increased when they rapidly ascentded to high altitude .With prolonging residence at high alti-tude,the ventricular repolarization duration gradually returned to the level on the plains ,suggesting that the the ventricular repolarization duration will be restored to its level on the sea level by the adaptation and adjustment mechanism of the body .

关 键 词：心室肌复极 高原 QT间期 QTC间期 TpTe间期 TpTec间期 

分 类 号：R542[医药卫生—心血管疾病]