中国人群肺结核发病危险因素的荟萃分析  被引量:52

Meta-analysis of risk factors of tuberculosis in China

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作  者:靳成娟[1,2] 杜建[3,4] 杨怀盛[1] 杨冬芳[5] 黄玉婷[1] 于旭亚[1] 申振伟 李秀君[1] 

机构地区:[1]山东大学公共卫生学院创新团队,济南250012 [2]山东大学医学院,济南250012 [3]北京市结核病胸部肿瘤研究所 [4]首都医科大学附属北京胸科医院,北京101149 [5]山东省泰安市疾病预防控制中心,泰安271000

出  处:《军事医学》2014年第5期355-359,364,共6页Military Medical Sciences

基  金:国家科技重大专项资助项目(2008ZX10003-008-02)

摘  要:目的:研究我国肺结核发病的主要危险因素,为今后肺结核的防治工作提供方向和依据。方法利用荟萃( Meta)分析的方法对2000~2012年国内外关于中国人群肺结核发病危险因素的25篇研究文献进行定量综合分析。结果肺结核接触史、吸烟、婚姻状况、人际交往、卡痕、卡介苗接种史、低体质量指数( BMI )、结核病家族史、工作暴露于粉尘环境和接触化学气雾的合并OR值(95%CI)分别为3.14(2.74~3.59),1.23(1.14~1.33),3.05(2.10~4.45),2.08(1.76~2.26),0.39(0.32~0.47),0.58(0.46~0.73),2.95(2.40~3.64),2.56(1.82~3.59),2.58(2.04~3.26),4.81(1.99~11.60)。结论肺结核接触史、吸烟、单身、人际交往频繁、低BMI、结核病家族史、工作暴露于粉尘环境和接触化学气雾是肺结核患病的危险因素,卡痕和卡介苗接种史是肺结核患病的保护因素。Objective To study the main risk factors related to the incidence of tuberculosis in China and to provide di -rections and basis for the protection of tuberculosis .Methods The results of 25 studies on the main risk factors of tubercu-losis of Chinese people from 2000 to 2012 were analyzed by meta-analysis method .Results The pooled odds radio values and 95%CI of history of exposure to pulmonary tuberculosis , smoking, marriage, contact with people, Bacille Calmette-Guerin (BCG)vaccination scar, BCG vaccination, low body mass index(BMI) , family history of tuberculosis, exposure to dust and to chemical fumes under working conditions were as follows:3.14(2.74-3.59),1.23(1.14 -1.33),3.05 (2.10-4.45),2.08(1.76-2.26),0.39(0.32 -0.47),0.58(0.46 -0.73),2.95(2.40 -3.64),2.56(1.82 -3.59),2.58(2.04-3.26),and 4.81(1.99-11.60).Conclusion Then History of exposure to pulmonary tuberculosis , smoking, marriage, contact with people , low BMI, family history of tuberculosis , exposure to dust and to chemical fumes under working conditions are considered to be the risk factors of pulmonary tuberculosis .While BCG vaccination scar and BCG vaccination are considered to be the protective factors of pulmonary tuberculosis .

关 键 词:肺结核 危险因素 荟萃分析 

分 类 号:R521[医药卫生—内科学]

 

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