载脂蛋白A-I/载脂蛋白B值对急性冠脉综合征患者的临床预测价值  

Predictive value of apolipoprotein A-I/apolipoprotein B ratio in patients with acute coronary syndrome

作　　者：李丰伟[1,2] 王能[1,2] 姚维[1,2] 钱进[1,2] 张振建[1,2] 

机构地区：[1]湖北医药学院附属随州医院 [2]随州市中心医院心血管内科,湖北随州441300

出　　处：《岭南心血管病杂志》2014年第3期314-316,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨不同血脂成分及载脂蛋白A-I(apolipoprotein A-I,apoA-I)/载脂蛋白B(apolipoprotein B,apoB)值对急性冠状动脉(冠脉)综合征的临床预测价值。方法收集586例胸痛患者行冠脉造影术的资料,其中急性冠脉综合征组426例,另外160例造影阴性者为对照组。测定并比较两组三酰甘油(TG),总胆固醇(TC),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C),apoA-I/apoB值及冠脉Gensini积分。结果急性冠脉综合征组apoA-I/apoB值明显高于对照组,差异有统计学意义(P<0.05)。apoA-I/apoB值与冠脉病变支数负相关(r=0.152,P=0.031)。结论 apoA-I/apoB值是急性冠脉综合征强有力的预测因子,且优于其他血脂指标。Objectives To explore the clinical predictive value of plasma apolipoprotein A-I （apoA-I）/apolipoprotein B （apoB）ratio and other lipid parameters for acute coronary syndrome （ACS）. Methods Totally 586 patients with chest pain undergoing coronary angiography （CAG） were included in this study. Among them, 426 cases were in ACS group, and 160 were in control group. Plasma total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, apoA-I/apoB ratio and other indexes were measured and analyzed between the two groups. Results The apoA-I/apoB ratio in ACS group was significantly higher than that in control group, and the difference was statistically significant （P〈0.05）. The apoA-I/apoB ratio was negatively correlated with the number of coronary artery lesions （r=0.152,P=0.031）. Conclusions The apoA-I/apoB ratio is a strong predictive factor for ACS, which is better than other lipid parameters.

关 键 词：冠状动脉疾病 载脂蛋白A 载脂蛋白B 

分 类 号：R541.4[医药卫生—心血管疾病]