手性硫脲对映选择性催化Henry反应研究  

The Research for Enantioselective Henry Reaction Catalyzed by Chiral Thiourea Derivatives

作　　者：陈盛楷 刘颖[1] 赵志伟[1] 赵博文[1] 买昊 鲜亮[1] 

机构地区：[1]西北民族大学化工学院,甘肃兰州730124

出　　处：《广东化工》2014年第12期14-15,共2页Guangdong Chemical Industry

基　　金：西北民族大学国家大学生创新创业训练计划项目(201310742005);留学人员科技活动项目择优资助项目(xbmu-2012-1313-62)

摘　　要：手性硫脲是不对称催化反应中一类典型的双功能有机小分子催化剂。文章合成了6种新型手性硫脲衍生物,以FT-IR和1H NMR进行了表征。同时以HPLC检测了手性硫脲催化剂在对映选择性催化Henry反应中的催化活性和对映选择性并获得了较高的产率和ee。实验证明,硫脲衍生物中氯元素取代基能够促进底物的活化,酰基硫脲的分子内氢键对催化剂的对映选择性催化具有较大的影响作用。Chiral thiourea derivative is one of typical bifianctional organic small catalyst in asymmetric catalysis. Six novel thiourea derivatives were synthesized and characterized by FT-IR and NMR. The enantioselective Henry Reaction catalyzed by the thiourea derivatives were also invested. The relatively high yield and ee were gained and the Chlorine substitute can promote the activation of substrate. The intramolecular hydrogen bond in acylthiourea has strong influence on the enantioselective catalysis.

关 键 词：手性硫脲 对映选择性 Henry反应 

分 类 号：TQ[化学工程]