分子烙印聚合物作为高效毛细管电泳添加剂的研究  

Molecular Imprinted Polymer Used as An Additive for High Performance Capillary Electrophoresis

作　　者：游静[1] 劳文剑[1] 陈淑莲[1] 欧庆瑜[1] 

机构地区：[1]中国科学院兰州化学物理研究所,甘肃兰州730000

出　　处：《分析测试学报》2001年第1期19-22,共4页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目 (29875033)

摘　　要：分子烙印聚合物 (molecularimprintedpolymer)是一种高选择的有分子记忆效应的主体分子 ,通常在非极性环境中制备和应用。该文在极性溶剂中利用离子化作用和疏水作用制备了非共价的分子烙印聚合物 ,并将其作为高效毛细管电泳流动相添加剂 ;在含水缓冲溶液条件下 ,研究了单体种类、分子烙印聚合物颗粒度和含量、缓冲溶液 pH值以及分离电压对分子烙印聚合物识别模板分子的影响。结果证明了在质子化溶剂中制备和应用非共价分子烙印聚合物是可行的。Molecular imprinted polymer is a kind of host molecules with high selectivity of molecular recognition. Usually such polymers are prepared and applied only in nonpolar solvents. Nevertheless, the authors, making use of the non _ covalent interaction __ hydrophobic and ionic interaction between the template and the functional monomer, succeeded to prepare a non _ covalent molecular imprinted polymer in the presence of the polar solvent. It was used as an additive in the mobile phase of high performance capillary electrophoresis. Effects of monomer species, particle size and content of the molecular imprinted polymer, buffer pH value, and applied voltage on the ability of molecular recognition of the synthesized molecular imprinted polymer have been studied in aqueous buffer media. The results showed that it was possible to prepare non _ covalent molecular imprinted polymers in polar solvents, and to use them in polar solvents as well.

关 键 词：分子烙印聚合物 高效毛细管电泳 添加剂 流动相 

分 类 号：O658.9[理学—分析化学]