胸腔内注入尿激酶辅助治疗结核性胸腔积液临床疗效观察  

Clinical observation of intrapleural injection of urokinase for patients with encapsulated tuberculous pleural effusion

作　　者：杨荣 李小芬 陈春霞 林娇 陈湛 李粼 

机构地区：[1]广东省湛江市结核病防治所结核病科,524008

出　　处：《白求恩医学杂志》2014年第3期232-233,共2页Journal of Bethune Medical Science

摘　　要：目的探讨尿激酶胸腔内注入辅助治疗结核性胸腔积液的临床效果。方法将90例结核性胸腔积液患者随机分为两组,各45例。对照组给予常规抗结核药物治疗,并采用中心静脉导管行胸腔闭式引流。观察组在对照组治疗的基础上行胸腔内注入尿激酶治疗。观察两组临床疗效指标、住院时间、并发症发生率及治疗效果。结果观察组胸液消失时间、热退时间、气促缓解时间、住院时间均短于对照组(P<0.01);观察组并发症发生率低于对照组(P<0.01);观察组临床总有效率高于对照组(P<0.05)。结论胸腔内注入尿激酶辅助治疗结核性胸腔积液临床疗效显著。Objective To investigate the clinical effect of intrapleural injection of urokinase for patients with encapsulated tuberculous pleural effusion. Methods Ninety patients were randomly divided into two groups（ n = 45,each）. The patients in the control group were treated with conventional treatment,and the central venous catheter closed drainage was used. On the basis of this,the patients in the observation group were treated with urokinase by intrapleural injection. The clinical efficacy indexes,the incidence and clinical effect were compared. Results The hydrothorax disappearance time,thermal annealing time,shortness of breath,remission time and the hospitalization time of the patients in the observation group were shorter than those in the control group（ P〈0.01）. The incidence rate in the observation group was lower than that in the control group（ P〈0.01）. The clinical total effect rate in the observation group was higher than that in the control group（ P〈0.05）. Conclusion The clinical effect of intrapleural injection of urokinase for patients with encapsulated tuberculous pleural effusion is significant.

关 键 词：尿激酶 结核性胸腔积液 中心静脉导管 胸腔闭式引流 

分 类 号：R521.7[医药卫生—内科学]