冠心病稳定型心绞痛的诊断研究  

Study of Diagnosis of Stable Angina Pectoris

作　　者：苏晓琳[1] 袁东超[1] 张哲[2] 吴瑾[1] 杨关林[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医杂志》2014年第6期1081-1083,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家科技部"重大新药创制"专项课题(2009ZX09502-29)

摘　　要：目的:深度挖掘冠心病稳定型心绞痛与理化指标及SAQ、SF-12、自评量表内条目间的相关性,探寻对该疾病有价值的诊断依据。方法:选择国内12所医院作为流行病调查分中心,采集符合入选标准的1788例门诊或住院患者及201例健康人的临床信息。采用Epidata 3.0建立数据库,SPSS 17.0软件统计分析。经过标准化处理后,采用Pearson相关性分析、logistic回归分析、判别分析、ROC分析逐步挖掘稳定型心绞痛与理化指标及量表内条目间的关系。结果:Pearson相关性分析示,可以认为67个变量与冠心病稳定型心绞痛相关(P<0.05);logistic回归分析筛选出8个变量与冠心病稳定型心绞痛相关(剔除标准P<0.10);判别分析示,冠心病稳定型心绞痛和健康人的判别函数:分类=0.282*颈动脉彩超+0.835*心电图-0.112*SAQ条目4-0.230*PCS-0.539*自评疾病维度值-0.152;判别结果的ROC曲线下面积=0.962。结论:颈动脉彩超、心电图、SAQ条目4、PCS(SF-12)、自评疾病维度值(自评量表)对稳定型心绞痛具有重要的诊断意义。Objective： To research the correlation between stable angina pectoris and physical and chemical indicators,the SAQ,the SF-12 and self-rating scale and to explore the most valuable basis for the diagnosis of the disease. Methods： The study selected 12 hospitals as sub-centers to collect the clinical information of 1788 cases of out-patient or hospitalized patients who met the inclusion criteria and 201 cases of healthy people. We established the database through Epidata 3. 0 and used SPSS 17. 0Software for statistical analysis. After standardization,we applied the Pearson correlation analysis,logistic regression analysis,discriminant analysis and ROC analysis to gradually explore the relationship between stable angina pectoris and physical and chemical indicators and each scale. Results： Pearson correlation analysis indicated that 67 variables were related with stable angina pectoris（ P〈 0. 05）. Logistic regression analysis filtered out 8 variables were related with stable angina pectoris（ excluding the standard P 〈 0. 10）. Discriminant analysis showed that the discriminant function of stable angina pectoris and healthy people： Category = 0. 282 × carotid color duplex ultrasonography ＋ 0. 835 × ECG-0. 112 × SAQ entry 4-0. 230 × PCS-0. 539 × dimension value of self-assessment diseases-0. 152. The area under ROC curve of discrimination results = 0. 962. Conclusion： Carotid color duplex ultrasonography,ECG,SAQ entry 4,PCS（ SF-12）,dimension values of self-assessment diseases（ self-rating scale）played significant roles in the diagnosis of stable angina pectoris.

关 键 词：稳定型心绞痛 流行病调查 Pearson相关性分析 LOGISTIC回归分析 判别分析 ROC分析 

分 类 号：R541.4[医药卫生—心血管疾病]