润肤消炎洗剂外用治疗特应性皮炎的疗效和安全性评价  

Efficacy and Safety of Anti-inflammatory Moisturizing Lotion on Atopic Dermatitis

作　　者：林颖[1] 陈达灿[1] 陈淑慧[1] 丁常清[1] 李红毅[1] 莫秀梅[1] 刘俊峰[1] 

机构地区：[1]广东省中医院大学城医院,广州510006

出　　处：《中国实验方剂学杂志》2014年第13期220-224,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广州中医药大学科研创新基金项目(09CX056)

摘　　要：目的:对润肤消炎洗剂外用治疗特应性皮炎(AD)的疗效和安全性进行评价。方法:纳入存在左右侧对称分布、且两侧皮损严重程度积分差值<2分的AD患者,采用自身左右对照的研究方法,治疗侧靶皮损和对照侧皮损采用相同的基础润肤治疗,治疗侧靶皮损加用润肤消炎洗剂外洗,对照侧皮损不应用,疗程2周,观察其临床疗效和安全性。结果:润肤消炎洗剂治疗2周后靶皮损和对照皮损的局部皮损积分、瘙痒分值统计有显著性差异(P<0.01),治疗后靶皮损急性、慢性皮损积分总和比较统计有显著性差异(P<0.01),急性皮损积分总和较慢性皮损积分总和下降明显(P<0.05)。轻、中度患者应用该药无刺激性,重度AD患者中4例在用药早期出现轻至中度可忍受的灼热和刺痛感。结论:润肤消炎洗剂对改善AD皮损和瘙痒疗效肯定;在治疗的2周疗程中对急性皮损的改善程度比慢性皮损明显。润肤消炎洗剂组方切合"心火亢盛、脾虚湿蕴"的病机,以"清心培土"为治法,适用于AD急性期和缓解期,抗炎、抑制AD皮肤金黄色葡萄球菌的定植和感染可能是其主要作用机制。润肤消炎洗剂应用安全,中、重度AD患者在用药前评估皮损的严重程度和敏感性,调节药物浓度、控制用药时间、温度等影响因素,注意洗浴后加强润肤治疗可减少不良反应的发生。Objective： The purpose of this research lies in the evaluation of efficacy and safety of the anti-inflammatory moisturizing lotion in treating atopic dermatitis （AD）. Method： The cases who have symmetrical and similar severity （severity score differs less than two） lesions on the limbs. Basic moisturizer was applied in both treatment side and control side, whereas anti-inflammatory moisturizing lotion was added to the treatment side, but control side not for 2 weeks. The clinical efficacy and safety were observed. Result： After 2 weeks, the score of the treatment target lesions and the control lesions had significant statistical difference （P 〈 0.01 ）, both the scores of the local pruritus had significant statistical difference （P 〈 0.01 ） which indicated that the anti-inflammatory moisturizing lotion could effectively improve the skin lesions and reduce pruritus. The total score and the pruritus score of target lesions decreased more significantly than the control lesions. Target lesions of acute and chronic lesions compared with total score was significant （P 〈 0.05）, which shows that the acute lesions give a more significant improvement compared with the chronic lesions. Thus using anti-inflammatory moisturizing lotion in acute inflammatory has a better outcome. There is not any uncomfortable sensation in those patients with mild to moderate in severity 4 cases of severe AD patients felt mild to moderate bearable burning and stinging on the skin. Conclusion： Anti-inflammatory moisturizing lotion can greatly improve lesion conditions and pruritus. Using anti-inflammatory moisturizing lotion in acute inflammatory has a better outcome compared with those chronic lesions in a 2 week＇s period of treatment. Anti-inflammatory moisturizing lotion is formulated according to the pathogenesis of ＇ flare-up of heart fire, insufficiency of spleen with dampness＇ , by using the ＇ purging the heart fire and tonify the spleen＇ method, it is suitable for both acute and remitting phase

关 键 词：润肤消炎洗剂 特应性皮炎 安全性 

分 类 号：R287.6[医药卫生—中药学]