牛蒡苷对小鼠急性毒性及神经系统的影响  

Acute toxicity of arctiin and its effects on the nervous system in mice

作　　者：张淑雅[1] 颜贝 王小萍[2] 芦晓红[1] 张宏[3] 裴秀英[1] 

机构地区：[1]宁夏医科大学生育力保持教育部重点实验室/生物化学与分子生物学系,宁夏银川750004 [2]宁夏医科大学总医院,宁夏银川750004 [3]第二军医大学药学院,上海200433

出　　处：《时珍国医国药》2014年第6期1281-1283,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81360094)

摘　　要：目的观察牛蒡苷对小鼠急性毒性及神经系统的影响,为牛蒡苷及牛蒡子的临床安全用药提供依据。方法采用灌胃和腹腔注射方法确定小鼠的半数致死剂量（LD50）。应用自发活动测试、戊巴比妥钠阈下催眠试验和协同催眠试验观察牛蒡苷对小鼠神经系统的影响。结果小鼠口服牛蒡苷的LD50为7.13g/kg,相当于人临床剂量的580倍;腹腔注射LD50为0.74g/kg,相当于人日口服剂量的60倍。口服0.122∽0.488g/kg剂量的牛蒡苷（相当于临床剂量的10,20和40倍）对神经系统无明显影响。结论牛蒡子药材临床口服途径应用安全,但非口服途径应慎重使用。Objective The acute toxicity of arctiin and its effects on the nervous system in mice were investigated to guide the clinical applications of arctiin and burdock fruits. Methods The median lethal doses （ LD50 ） were determined by garage and in- traperitoneal injection in mice. The effects of arctiin on the nervous system of mice were evaluated using spontaneous activity test, synergetic hypnosis test and hypnosis test under field value. Results The oral LDs0 was 7.13 g/kg,which is equivalent to 580 times of the clinical dose used. The intraperitoneal LD50 was 0.74 g/kg, which is equivalent to 60 times of the oral clinical dose used. In addition,we did not observe the effects of arctiin on the nervous system of mice at the dose of 0. 122-0.488 g/kg （appropriately 10,20 and 40 times of clinical dose used）. Conclusion Burdock fruits can be used safely by oral approach,but non - oral routes should be used cautiously.

关 键 词：牛蒡苷 毒性 神经系统 

分 类 号：R285.5[医药卫生—中药学]