半夏泻心汤治疗慢性萎缩性胃炎的meta分析  

A Meta-Analysis of Banxia Xiexin Decoction in Treatment of Chronic Atrophic Gastritis

作　　者：廖纬琳[1] 陈国忠[2] 夏李明 

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学第一附属医院,广西南宁530023 [3]广西来宾市中医医院,广西来宾546100

出　　处：《时珍国医国药》2014年第6期1526-1529,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81260529);广西自然科学基金项目(No.2011GXNSFA018297);广西医疗卫生重点科研课题(No.重201157)

摘　　要：目的评价半夏泻心汤治疗慢性萎缩性胃炎(CAG)的临床疗效。方法计算机检索PubMed、万方数据库、维普网、中国期刊全文数据库(CNKI)中发表的针灸治疗慢性萎缩性胃炎的临床随机对照试验,按照RCT质量评价的修改后Jadad量表评价标准对纳入文献进行质量评价,使用Revman 5.2统计软件进行Meta分析统计学处理,评价胃复春治疗慢性萎缩性胃炎的临床疗效和安全性。结果共纳入15个研究,包括1208例患者。Meta分析结果显示:与对照组相比,半夏泻心汤治疗CAG在临床总有效率、胃镜检查改善情况、CAG腺体萎缩改善情况、HP转阴率、症状积分等方面均显示出较好的疗效。结论研究表明,半夏泻心汤治疗慢性萎缩性胃炎有较好疗效,但还需高质量的随机对照试验进一步验证支持。Objective To systematically evaluate the efficacy of Banxia Xiexin Decoction in the treatment of chronic atrophic gas- tritis. Methods According to strict inclusive and exclusive criteria, through electronic searches of relevant randomized controlled trials （RCTs） on Banxia Xiexin Decoction for chronic atrophic gastritis in PubMed（ 1990 to Auqust,2013）, WanFang Data（ 1990 to August,2013） ,WeiPu Data（ 1990 to August,2013）and CNKI（ 1990 to August,2013）. Two reviewers independently screened articles according to the inclusion and exclusioncriteria, extracted data and evaluated the quality of the included studies. All re- viewed literatures were assessed via Jadad quality scale. Data statistical analyses were performed by RevMan 5.2 software. Re- suits A total of 15 trials involving 1208 patients were included. Meta- analysis showed that compared with the control group, Banxia Xiexin Decoction significantly improved excellent response rate,overall response rate,gastroscope mucous membrane ,path- ological symptoms （ atrophy）, negative conversion of Heticobacter pylori infection, the total odd ratios （OR） were 5.11, [ （ 95 % confidence interval （CI） = 3.67,7.11 ） ], 4.38,95 % CI = （2.22,8.64）, 2.47,95 % CI = （ 1.11,5.52 ）, 20,95 % CI = （ 0.88,5. 46 ） ,3.27,95 % CI = （0.90,11.87 ）, and 4.37,95 % CI = （ 2.67,7.15 ）, respectively, and the improvement of symptoms （ epigas- tric pain, distention and fullness, poor appetite） weight mean difference （WMD） were - 1.10,95 % CI （ - 2.17, - 0.03 ）, - 1.04, 95 % CI （ - 1.70, -0.38 ）, -0.57,95 % CI （ - 1.08, -0.05 ）, respectively. No significant difference was noted in the total OR of pathological symptoms （ intestinal metaplasia, dysplasia） and improvement of symptoms （ belching, noisy） between the two groups （P 〉 0.05 ）. Conclusion Banxia Xiexin Decoction treatment for chronic atrophic gastritis shows curative effect. However, due to lack of enough high - quality studies, has to be further st

关 键 词：慢性萎缩性胃炎 半夏泻心汤 随机对照试验 META分析 

分 类 号：R289[医药卫生—方剂学]