降钙素原及和肽素检测在急性胰腺炎中的诊断意义  

The clinical significance of procalcitonin and copeptin in acute pancreatitis

作　　者：谢飞[1] 吴丹[2] 李晓强[1] 

机构地区：[1]湖北医药学院附属太和医院检验科,湖北十堰442000 [2]湖北省十堰市中心血站检验科,442000

出　　处：《检验医学与临床》2014年第12期1632-1633,共2页Laboratory Medicine and Clinic

摘　　要：目的研究血清降钙素原(PCT)及和肽素(Copeptin)的表达水平在急性胰腺炎(AP)中的临床意义。方法对该院2011年8月至2013年8月66例AP患者进行回顾性分析,其中重症胰腺炎(SAP)28例,轻型胰腺炎(MAP)38例,另选取30例健康体检者作为健康对照组。分别测定不同时间段SAP患者和健康对照者血清中PCT和Copeptin的水平。结果 (1)与健康对照者比较,入院后第1、2、7天MAP和SAP患者血清PCT水平明显升高,差异有统计学意义(P<0.05),而第14天只有SAP患者升高,第1、2、7、14天MAP和SAP患者PCT水平之间差异有统计学意义(P<0.05)。(2)与健康对照者比较,入院后第1、2天MAP和SAP患者的血清中均明显升高,差异有统计学意义(P<0.05),而第7天只有SAP患者升高,在第1、2、7天Copeptin在MAP和SAP患者之间,差异有统计学意义(P<0.05)。(3)PCT在SAP的阳性率为92.9%,明显高于在MAP中的阳性率,差异有统计学意义(P<0.05)。结论 PCT和Copeptin是AP早期诊断较好的指标,且PCT能更好地判断疾病的预后。Objective To study the clinical application value of the serum procalcitonin （PCT ） and copeptin in patients with acute pancreatitis （AP） .Methods The data of patients with AP from Aug 2011 to Aug 2013 were ana-lyzed ,which was divided into the severe acute Pancreatitis （SAP） and the mild acute Pancreatitis （MAP） ,30 healthy subjects were chosen to control group .The concentrations of PCT and copeptin in serum were detected at 1 ,2 ,7 ,14 day ,respectively .Results （1） Compared with those in the control group ,serum level of PCT in all AP patients were significantly increased（P〈0 .05） at 1 ,2 ,7day and inspectively increased at 14 day .PCT level in the SAP group were higher than those in the MAP group at 1 ,2 ,7 ,14 respectively （P〈 0 .05） .（2）Compared with those in the control group ,serum level of copeptin in all AP patients were significantly increased （P〈0 .05） at 1 ,2 ,day and inspectively increased at 7 day in the SAP groups .Copeptin level in the SAP group were higher than those in the MAP group at 1 ,2 ,7 ,respectively（P〈0 .05） .（3）the positive rate of PCT in the SAP and MAP group were 92 .9% and 78 .9% ,re-spectively ,the different was statistically significant（P〈0 .05） .Conclusion The detection of the PCT and copeptin is helpful for early diagnosing AP ,and the PCT than copeptin can better forecast the prediction of diagnosis .

关 键 词：降钙素原 和肽素 急性胰腺炎 

分 类 号：R51[医药卫生—内科学]