2010～2012年假丝酵母菌株的分布及耐药性分析  

Vulvovaginal candidiasis strain distribution and resistance analysis form 2010 to 2012

作　　者：邹云芝[1] 文业华[2] 

机构地区：[1]湖北省荆门市第一人民医院健康管理科,448000 [2]湖北省荆门市第一人民医院检验科,448000

出　　处：《检验医学与临床》2014年第12期1636-1637,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨患者假丝酵母菌病(VVC)的致病菌株分布及药敏情况。方法对2010年1月至2012年12月该院进行阴道分泌物病原学检测结果进行回顾性调查分析。结果 3年检出VVC患者阳性数分别为248、291、381例,患者例数逐年增加;假丝酵母菌中非白假丝酵母菌比例逐年增加,分别为11.69%、18.21%和24.67%,差异有统计学意义(P<0.01);非白假丝酵母菌对咪康唑、伊曲康唑等常用抗真菌药物耐药率逐年上升,分别从6.90%和24.14%上升至11.89%和37.23%,分别与前1年比较差异有统计学意义(P<0.05)。结论 VVC患者例数逐年增加,随着时间的推移,VVC的致病菌株以及其耐药性在一定程度上发生了改变。对VVC的治疗应重视其致病菌株的检测,并根据药敏试验结果合理选择抗真菌药物,提高VVC的治愈率。Objective To investigate distribution situation and its susceptibility of vulvovaginal candidiasis （VVC） pathogenic strains and its susceptibility ,to facilitate the effective treatment of the disease .Methods Test re-sults of pathogenicvaginal secretions of laboratory department in a hospital from 2010 to 2012 were retrospectively analyzed .Results From 2010 to 2012 ,the numbers of VVC-positive patients is 248 ,291 ,381 respectively which in-crease every year .The proportion of non-albicans in candidiasis were 11 .69% ,18 .21% and 24 .67% ,which increases every year ,the difference was statistically significant （P〈0 .01） .Drug resistance rate of non-albicans to miconazole , itraconazole and other commonly usedantifungal drug is increased year by year ,to be exact ,from 6 .90% ,24 .14% up to 11 .89% ,37 .23% ,it is significantly different compared with the previous year （P〈0 .05） .Conclusion The num-ber of VVC patients increased year by year .Over time ,VVC of pathogenic strains as well as resistance of pathogenic strains have changed to some extent ,in the course of VVC treatment should pay attention to the detection of patho-genic strains ,and a reasonable choice of antifungal agents should be based on susceptibility testing results to improve the cure rate of VVC .

关 键 词：外阴阴道假丝酵母菌病 菌株分布 耐药分析 

分 类 号：R711.31[医药卫生—妇产科学]