丹红注射液对不稳定型心绞痛血瘀证患者经皮冠状动脉介入术围手术期血管内皮功能的影响  

Effects of Danhong Injection(丹红注射液) on Endothelial Function of Perioperative Unstable Angina Patients With Blood Stasis Syndrome Undergoing Percutaneous Coronary Intervention

作　　者：董静[1] 陈韵岱[1] 刘红旭[2] 陈劲松[1] 周迎[1] 王晶[1] 田峰[1] 

机构地区：[1]中国人民解放军总医院,北京市海淀区复兴路28号100853 [2]首都医科大学附属北京中医医院

出　　处：《中医杂志》2014年第13期1109-1112,共4页Journal of Traditional Chinese Medicine

基　　金：首都医学科技发展基金资助项目(SF-2009-Ⅰ-12)

摘　　要：目的观察丹红注射液对不稳定型心绞痛血瘀证患者冠状动脉介入治疗（PCI）术后血管内皮的保护作用及其机制。方法100例接受PCI的不稳定型心绞痛血瘀证患者随机分为丹红组和常规组各50例，两组均在PCI术前l～3天给予西医常规治疗，丹红组同时接受丹红注射液40ml静脉滴注，两组术后继续应用4～6天（围手术期共应用7天）。于给药前后检测血清超氧化物歧化酶（SOD）、丙二醛（MDA）和血管性血友病因子（vWF）、可溶性细胞间粘附分子-1（sICAM-1），PCI术前及术后第2天分别检测血流介导肱动脉舒张功能（FMD）。结果丹红组给药后SOD较给药前升高，MDA、vwF、sICAM-1降低（P〈0．05）；常规组给药后SOD较给药前降低，MDA、vWF、sICAM-1升高（P〈0．05）。两组治疗后FDM均较治疗前明显降低（P〈0．05），治疗后两组间比较，常规组亦明显低于丹红组（P〈0．05）。结论丹红注射液可以通过减轻氧化应激对血管内皮的损伤，改善PCI术后血管内皮功能。ABSTRACT Objective To observe the protective effect and mechanism of Danhong Injection （丹红注射液） on en- dothelial function of perioperative unstable angina （UA） patients with blood stasis syndrome undergoing percutaneous coronary intervention （PCI）. Methods Totally 100 UA patients with blood stasis syndrome undergoing PCI were randomized into the Danhong group and routine group, with 50 in each. Both groups were given conventional treat- ment 1 to 3 days before PCI. Danhong group was added with intravenous infusion of 40 ml Danhong Injection （丹红注射液）. The administration lasted for 4 to 6 days in both groups after operation （ lasted for 7 days in total during the perioperative period）. The levels of superoxide dismutase （SOD）, malondialdehyde （MDA）, yon Willebrand factor （vWF） and soluble intercellular adhesion molecule-1 （slCAM-1） were detected before and after medication. The flow-mediated dilation （FMD） of brachial artery was detected before PCI and 2 days after PCI. Results The SOl） level was significantly increased but the levels of MDA, vWF and sICAM-1 were significantly decreased in the l）an- hong group after medication （P 〈 0. 05 ）. The SOD level was significantly decreased but the levels of MDA, vWF and slCAM-1 were significantly increased in the routine group after medication （P 〈 0.05）. The levels of FDM were sig- nificantly decreased in both groups after medication （ P 〈 0.05 ）, especially in the routine group （ P 〈 0.05 ）. Conclusion Danhong Injection （丹红注射液 can improve the endothelial function after PCI by reducing the endo- thelial injury of oxidative stress.

关 键 词：不稳定型心绞痛 丹红注射液 经皮冠状动脉介入 内皮功能 氧化应激 

分 类 号：R541.4[医药卫生—心血管疾病]