表观遗传对老年人群抗精神病药疗效的调节:组蛋白脱乙酰基酶抑制剂的临床前研究(英文)  

Epigenetic regulation on antipsychotic efficacy in the elderly population:preclinical aspects of histone deacetylase inhibitors

作　　者：董红心[1] Janitza Montalvo-Ortiz John Csernansky 

机构地区：[1]西北大学芬伯格医学院精神病学和行为科学教研室

出　　处：《遵义医学院学报》2014年第3期255-262,共8页Journal of Zunyi Medical University

摘　　要：抗精神病药已被广泛地用于治疗老年人的精神性严重疾病,包括精神分裂症和伴有认知功能受损的行为障碍。这种用药不仅未达到预期的治疗效果,相反,还给老年人带来了一系列的不良反应。但涉及的机制目前仍不清楚,而年龄相关的表观遗传改变可能是其机制之一。本综述主要介绍与年龄相关的表观遗传改变及其对老年人使用抗精神病药效果的影响。重点讨论动物模型中组蛋白脱乙酰基酶抑制剂(HDAci)改变老年表观遗传从而增强抗精神病药的潜在的表观遗传改变。了解对药物疗效表观遗传效应的作用机制,有助于在使用抗精神病药的老年人群中发现增强药效降低不良反应的新策略。Antipsychotic drugs are widely prescribed to elderly patients for the treatment of a variety of psycho-pathological conditions including psychosis and behavioral disturbances associated with cognitive impairment.However,the outcomes of treatments are not as effective as expected and the severity of side effects is prominent in the elderly.While the mechanisms are not well understood,the age-related epigenetic alterations may be the one of the mechanisms.The aim of this review is to introduce the epigenetic alterations with aging and its impacts on the antipsychotic drug efficacy in this population.In particular,this review discusses the potential epigenetic correction by treatment of histone deacetylase inhibitors（HDACis） to increase antipsychotic drugs efficacy in animal models.Understanding the mechanisms underlying epigenetic effects on drug efficacy will help develop new strategies to increase benefits and decrease side effects of psychotropic medications in the elderly population.

关 键 词：抗精神病药 老年人群 表观遗传效应 组蛋白脱乙酰基酶抑制剂 

分 类 号：Q422[生物学—神经生物学]