血必净注射液对脓毒症合并急性肾损伤患者的肾功能及血清IL-6、TNF-α的影响  

Impact of Xuebijing injection on renal function and serum IL-6 and TNF-α in patients with sepsis and acute kidney injury

作　　者：林秀娟[1] 田育红[1] 唐纪文 徐宝仪 

机构地区：[1]惠州市中医医院药房,广东惠州516001 [2]博罗县九潭医院,广东博罗516129

出　　处：《海南医学》2014年第12期1774-1776,共3页Hainan Medical Journal

摘　　要：目的探讨血必净注射液对脓毒症合并急性肾损伤(AKI)患者的肾功能及血清IL-6、TNF-α的影响。方法 38例脓毒症合并AKI患者随机分为两组,对照组予常规治疗,观察组在此基础上联合应用血必净注射液,比较治疗前后肾功能及血清IL-6、TNF-α的变化及需要血液净化治疗的比例和死亡率的差异。结果治疗7 d后,观察组肾功能指标Scr、BUN及炎症指标IL-6、TNF-α水平均明显低于对照组,差异有统计学意义(P<0.05);观察组接受血液净化治疗的比例为21.05%,明显低于对照组的47.37%,差异有统计学意义(P<0.05);两组患者死亡率比较差异无统计学意义(P>0.05)。结论血必净注射液可降低脓毒症AKI患者血清IL-6、TNF-α的水平,改善患者肾功能指标,对肾功能具有明显的保护作用。Objective To investigate the impact of Xuebijing injection on renal function and serum IL-6 and TNF-αin patients with sepsis and acute kidney injury. Methods Thirty-eight patients with sepsis and AKI were ran-domly divided into two groups. The control group received conventional treatment, and the observation group re-ceived added Xuebijing injection. Renal function and serum IL-6 and TNF-αwere compared as well as the proportion of blood purification treatment and mortality. Results After 7days treatment, the levels of renal function （Scr and BUN） and inflammatory markers （IL-6 and TNF-α） in observation group were significantly lower than those in the control group （P〈0.05）. The proportion of blood purification treatment in observation group was 21.05%, which was significantly lower than that in the control group as 47.37% （P〈0.05）. The mortality difference between the two＆amp;nbsp;groups were not of statistically significant （P〉0.05）. Conclusion Xuebijing injection can reduce serum IL-6 and TNF-αlevels in patients with septic and AKI, and improve renal function. It has a significant protective effect on re-nal function.

关 键 词：脓毒症 急性肾损伤 血必净注射液 炎症介质 

分 类 号：R631.2[医药卫生—外科学]