乌司他丁对脓毒血症患者免疫功能的影响  

Effect of ulinastatin on immune function in patients with sepsis

作　　者：张宇[1,2] 丁国娟[1,2] 陈亚涛[1,2] 

机构地区：[1]绍兴市人民医院 [2]浙江大学绍兴医院急诊科,绍兴312000

出　　处：《实用药物与临床》2014年第6期728-730,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨乌司他丁对脓毒血症患者免疫功能的影响。方法将106例脓毒血症患者随机分为对照组和观察组,每组53例。两组患者均接受常规治疗,观察组患者同时给予乌司他丁。于治疗前后抽取患者外周静脉血,检测其淋巴细胞亚群和TNF-α、IL-10并进行分析。结果治疗前,两组患者血清CD3+、CD4+、CD8+水平,CD4+/CD8+比值以及TNF-α和IL-10水平比较差异无统计学意义(P>0.05)。治疗后,观察组患者CD3+、CD4+水平及CD4+/CD8+比值明显优于对照组患者(P<0.05),但两组患者CD8+水平比较差异无统计学意义(P>0.05);治疗后,观察组TNF-α及IL-10水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论乌司他丁可有效改善脓毒血症患者的免疫功能。Objective To investigate the effects of ulinastatin on immune function in patients with sepsis. Methods 106 cases of sepsis patients were randomly divided into control group and observation group,53 cases in each group. All patients received conventional treatment,and observe group was given ulinastatin at the same time. Before and after treatment,the peripheral blood of all patients was extracted to detect lymphocyte subsets and TNF-α,IL-10. Results Before treatment,the levels of CD3＋,CD4＋,CD8＋,CD4＋/CD8＋ratio,TNF-α and IL-10 of the two groups had no significant difference（ P〉 0. 05）. After treatment,the levels of CD3＋,CD4＋and CD4＋/CD8＋ratio of the observation group were significantly improved,better than those of the control group（ P〈0. 05）. While the CD8＋levels of the two groups had no significant difference（ P 〉0. 05）. After treatment,the levels of TNF-α and IL-10 of the observation group were significantly lower than those of the control group,the difference had significant difference（ P〈0. 05）. Conclusion Ulinastatin can improve immune function in patients with sepsis.

关 键 词：乌司他丁 脓毒血症 免疫功能 

分 类 号：R459.7[医药卫生—急诊医学]