二氯乙酸钠电纺纤维毡改善宫颈癌小鼠生存质量  

Improved Suvival Quality of Mice with Cervical Cancer Through the Therapy of Sodium Dichloroacetateloaded Electrospun Mats

作　　者：刘大兴[1,2] 王明哲[1] 景遐斌[1] 黄宇彬[1] 

机构地区：[1]中国科学院长春应用化学研究所,长春130022 [2]中国科学院大学,北京100049

出　　处：《应用化学》2014年第7期763-769,共7页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(51273194;51021003;50733003;21174143);吉林省科技厅项目(20100588)资助~~

摘　　要：通过溶液静电纺丝的方法,将水溶性药物二氯乙酸钠(DCA)包裹入油溶性聚乳酸(PLA)中,制备出二氯乙酸钠电纺纤维毡。将其应用于宫颈癌的活体实验中,结果表明在为期19 d的治疗下,荷瘤小鼠的肿瘤抑制率达到94%,总体康复率达到38%。同时,DCA电纺纤维毡还极大地抑制了宫颈癌后期复发和转移的趋势,提高了荷瘤小鼠的生存质量,是一种安全且疗效确切的抗癌给药剂型。Solidum dichloroacetate（DCA） loaded electrospun mats was fabricated through the solution electrospun method.When applying this DCA-loaded electrospun mats on the therapy of the subcutaneous cervical cancer model,a 94％ tumor suppression rate and an overall 38％ recovery rate were achieved after 19 days＇ treatment.The trend of recurrence and metastasis was also significantly inhabited.Meanwhile,DCA-loaded electropsun mats improved the life quality of tumor-bearing mice fundamentally.Therefore,DCA administrated by electrospun mats is a safe approach for the treatment of anti-cervical cancer.

关 键 词：宫颈癌 二氯乙酸钠 静电纺丝 生存质量 

分 类 号：O615.4[理学—无机化学]