广东地区1996年流感暴发的分子变异基础  

Molecular Evolution of Guangdong Influenza Virus Isolates in Influenza Outbreak in 1996

作　　者：黄平[1] 沈桂章[1] 倪汉忠[1] 周惠琼[1] 

机构地区：[1]广东省疾病预防控制中心

出　　处：《中国病毒学》2001年第1期1-5,共5页Virologica Sinica

基　　金：世界卫生组织资助项目 !(WP/ICP/PHC/ 0 14 /VD/ 94) ;CDC资助项目! (E80 90 30 )

摘　　要：1996年广东地区流感毒株发生明显的血清学抗原漂移 ;引起广东地区流感暴发的分子基础是流感毒株HA基因编码的A、B、C、D和E五个抗原决定簇位点变异 ,尤其是A、C、E位点发生氨基酸改变 ;而受体结合位点的氨基酸改变对此流感流行未发挥明显影响。HA基因编码氨基酸的第 145号和第 193号位点变异导致流行毒株的生物学特性改变 ,即分离毒株适应于MDCK细胞株生长 。It was demonstrated that there was significantly antigenic drift in the influenza virus strains from Guangdong in 1996. It was the molecular basis of the variation on A、B、C、D and E domain encoded by HA gene, especially on A、C and E domain while the change of receptor binding domain played the slight roles in the 1996 influenza outbreak. In the other hand, the variation of No 145 and No 193 encoded by HA gene resulted in biological feature changes of epidemical influenza isolates, which could be isolated and cultured by MDCK cell lines, but difficultly by embryonated eggs.

关 键 词：流感病毒 血凝素基因 变异 广东 

分 类 号：R181.3[医药卫生—流行病学]