跳动心脏的心电仿真模型建构  

THE CONSTRUCTION OF THE ELECTROCARDIOGRAPHIC SIMULATION MODEL OF BEATING HEART

作　　者：张力锋[1] 吴国华[1] 夏灵[1] 

机构地区：[1]浙江大学生命科学与医学工程学系,浙江杭州310027

出　　处：《生物物理学报》2001年第1期114-122,共9页Acta Biophysica Sinica

基　　金：全国优秀博士学位论文项目!课题;夏灵 ;1999;国家自然科学基金!资助项目(39700032)

摘　　要：以往的心电仿真研究都没有考虑在一个心动周期内,因为心脏跳动而引起的偶极子位置变化的实际情况,从而造成其结果输出的不可避免的误差。在心脏电生理和心脏动力学分析的基础上,对原有的心脏电仿真模型施加动力学影响,从而构建了新的跳动心脏模型。在这两个模型上进行了正常心脏和心肌缺血心脏的仿真试验后,对比两个心电模型的仿真输出,发现新的心脏模型有效提高了仿真精度,对于严重心肌缺血和轻微心肌缺血的识别分别有不同程度的改善。这项研究证实了动力学因素在心电模型建构中的重要性,为心电正问题和逆问题研究的进一步开展提供了新的思路和方向。Previous electronic cardiac graphic(ECG) simulation works always ignore the displacement of the equivalent dipole region caused by heart throb in one cardiac cycle, which made their models' output electrocardiograms have unavoidable errors especially during the ST-T segment. Based on the analysis of electrocardic and mechanical physiology of the human heart, we try to impose the mechanical factor on our electronic heart model. So a new dynamic electronic heart model was constructed. Comparing these two models' output BSPM under the normal and ischemia situation, we found the new model improved the precision of the ECG simulation. This research work substantiates the importance of the mechanical factor in the ECG simulation, and provider a new orientation for exploring the further electrocardiographic forward problem and inverse problem.

关 键 词：心电仿真模型 心脏动力学 心肌缺血 体表电位图 心电正问题 心电逆问题 

分 类 号：R540.4[医药卫生—心血管疾病]