无预防性应用抗菌药物对感染高危患者PCI术后感染的影响  

Effects of of without Prophylactic Application of Antibiotics on Postoperative Infection in High Risk Patients after PCI Operation

作　　者：陈方[1] 张小勇[2] 钟国权[3] 温星来 钟键敏[1] 陈素敏[2] 

机构地区：[1]暨南大学医学院附属清远市人民医院药剂科,广东清远511518 [2]暨南大学医学院附属清远市人民医院胸心中心,广东清远511518 [3]暨南大学医学院附属清远市人民医院检验科,广东清远511518 [4]暨南大学医学院附属清远市人民医院统计室,广东清远511518

出　　处：《中国药房》2014年第26期2437-2438,共2页China Pharmacy

基　　金：广东省清远市2013年科技计划项目(No.2013B045)

摘　　要：目的:探讨无预防性应用抗菌药物对感染高危患者经皮冠状动脉介入治疗(PCI)术后感染的影响。方法:将我院行PCI的195例患者,按是否有高龄(>70岁)、糖尿病等感染高危因素分为高危组(n=84)与非高危组(n=111),PCI围术期均无预防性应用抗菌药物。观察两组患者术后体温、白细胞变化和伤口愈合情况,对比两组患者PCI术后感染和疑似感染的发生率。结果:所有患者穿刺部位愈合良好,两组患者PCI术后感染发生率均为0%,高危组与非高危组PCI术后疑似感染发生率分别为30.95%和30.63%(P>0.05);高危组患者术后白细胞升高26例,无发热等临床症状。结论:感染高危患者PCI无预防性应用抗菌药物是可行的,PCI术后感染与预防性应用抗菌药物无关联性。严格无菌技术操作是减少PCI术后感染的关键。OBJECTIVE： To investigate the effect of without prophylactic application of antibiotics on postoperative infection in high risk patients after PCI operation. METHODS： 195 patients underwent PCI in our hospital were divided into high risk group （n= 84） and non-high risk group （n=111 ） according to high risk factor as advanced age （〉70 years old） and diabetes mellitus. All patients were treated with antibiotics without prophylactic application. Body temperature, leukocyte and wounds healing of 2 groups were observed. The incidence of postoperative infection and suspected infection were compared between 2 groups after PCI operation. RESULTS： All punctures healed well. The incidences of infection after PCI in 2 groups were both 0. The incidences of suspected in- fection after PCI were 30.95% in high risk group and 30.63% in non-high risk group （P〉0.05）. 26 high-risk cases suffered from in- crease of leucocyte count without other clinical symptoms as fever. CONCLUSIONS： It is feasible that PCI high risk patients can be treated without prophylactic application of antibiotics. No relationship is found between PCI postoperative infection and prophylactic application of antibiotics. Strict aseptic operation is crucial to minimize the risk of infection after PCI.

关 键 词：抗菌药物 感染 经皮冠状动脉介入治疗 

分 类 号：R197.323[医药卫生—卫生事业管理] R978.1[医药卫生—公共卫生与预防医学]