TNF-α、SP-A在儿童不同程度肺炎中的表达和临床意义  

TNFα, SP-A expression and clinical significance of varying degrees of pneumonia in children

作　　者：周佳磊[1] 徐冬新[1] 李仪[1] 陈志敏[2] 

机构地区：[1]杭州市萧山区第一人民医院检验科,浙江杭州311200 [2]浙江大学附属儿童医院呼吸科,浙江杭州310003

出　　处：《中国现代医生》2014年第18期145-147,共3页China Modern Doctor

基　　金：国家自然科学基金(81070004)

摘　　要：目的观察不同程度小儿肺炎时,血清致炎性因子肿瘤坏死因子(TNF-α)、肺表面活性蛋白A(SP-A)表达含量的变化及其临床意义。方法将195例肺炎儿童根据病情严重程度将其分为普通肺炎患儿及重症肺炎患儿,另外选择65例非肺炎患儿作为对照组,采用ELISA方法检测不同程度肺炎血清中的TNF-α和SP-A水平。结果TNF-α、SP-A在普通、重症肺炎患儿血清中表达水平显著升高,且重症肺炎组的TNF-α、SP-A表达水平显著高于普通肺炎组。结论在小儿重症肺炎患儿发病过程中,血清中肿瘤坏死因子TNF-α和肺表面活性蛋白SP-A的表达水平明显增多,可以反映肺损伤程度,可作为临床检测指标。Objective To observe the expression levels change and it＆#39;s clinical significance of TNF-α, SP-A in chil-dren with varying degrees of pneumonia. Methods A total 195 cases of pneumonia children patients were divided into ordinary pneumonia and severe pneumonia patients , another 65 cases of non-pneumonic children patients as the con-trol group, ELISA assay was used to detect serum TNF-α and SP-A level. Results The levels of serum SP-A and TNF-αof pneumonia children group were higher than the control group＆#39;s , and severe pneumonia patients ’ were high-er than ordinary pneumonia. Conclusion The expression level of TNF-α and SP-A increased significant in the patho-genesis of children with severe pneumonia which could reflect the degree of lung injury and as a indicator in clinical testing.

关 键 词：儿童肺炎TNF—α 肺表面活性蛋白A(SP—A) 血清 

分 类 号：R725.6[医药卫生—儿科]