不同年龄组妊娠期高血压疾病患者血清Apelin水平对比研究  

Comparative study of serum apelin levels of patients with hypertensive disorder complicating pregnancy of different age groups

作　　者：樊玲清 黄建勇 刘秋霞[1] 王国标[3] 王荣辉[4] 戴晓燕 王敏[1] 向剑平 吴岚[7] 

机构地区：[1]广东省惠州市大亚湾区人民医院妇产科,广东惠州516081 [2]广东省惠州市大亚湾区霞涌医院心血管内科,广东惠州516082 [3]广东省惠州市中心人民医院急诊科,广东惠州516001 [4]广东省惠州市惠阳区人民医院妇产科,广东惠州516211 [5]广东省惠州市惠城区红十字会医院妇产科,广东惠州516008 [6]广东省惠州市中大惠亚医院医务科,广东惠州516081 [7]广东省惠州市大亚湾区人民医院医院办公室,广东惠州516081

出　　处：《中国现代医生》2014年第19期19-21,24,共4页China Modern Doctor

摘　　要：目的探讨不同年龄组妊娠期高血压疾病(DHCP)患者血清Apelin水平的差别。方法 DHCP患者为观察组,正常妊娠者为对照组。观察组按年龄段分成5个小组,A组(≥20周岁)、B组(≥25周岁)、C组(≥30周岁)、D组(≥35周岁)、E组(≥40周岁、<45周岁)。每小组各按时间顺序入选妊娠高血压、轻度子痫前期、重度子痫前期各10例。对照组为按上述的年龄段在正常妊娠者中各选6例组成。入选对象在孕37周加1至38周时进行血清Apelin检测,然后将观察组各小组血清Apelin进行比较并与对照组对比分析。结果观察组各小组血清Apelin水平均高于对照组,而且,随着年龄增加愈加显著,其中E组高于D组,D组高于C组,C组高于B组,均有统计学意义(P<0.01)。血清Apelin水平与各小组患者的SBP、DBP水平呈正相关,均有统计学意义。结论DHCP的发生发展与其血清Apelin水平密切相关,而且,随着年龄增长愈加显著。血清Apelin水平可作为DHCP的危险因素。Objective To investigate the differences in serum Apelin levels between the patients with hypertensive disorder complicating pregnancy （HDCP） of different age groups. Methods The patients with HDCP served as the observation group and the patients with normal pregnancy served as the control group. The observation group were divided into 5 subgroups according to the age group, namely subgroup A （≥ 20 years old）, subgroup B （≥ 25 years old）, subgroup C （≥30 years old）, subgroup D （≥35 years old） and subgroup E （≥40 years old and 〈45 years old）. In each subgroup, 10 patients with HDCP, 10 patients with mild preeclampsia and 10 patients with severe preeclampsia were selected according to the chronological order. In the control group, 6 patients were selected respectively according to the above age group. The selected subjects received serum Apelin detection on the 37th week plus 1 to the 38th week of pregnancy, and then the serum apelin of the observation group was compared between each subgroup and to the control group. Results The serum apelin level of each subgroup of the observation group was higher than that of the control group and became more significant as the age increased, of which subgroup E was higher than subgroup D, subgroup D was higher than subgroup C, and subgroup C was higher than subgroup B, with statistical significance （P〈 0.01）. The serum Apelin level was positively correlated to the SBP and DBP levels of each subgroup, with statistical significance. Conclusion The development of HDCP is closely related to the serum Apelin level and becomes more significant as the age increases. The serum Apelin level can serve as the risk factor of HDCP.

关 键 词：不同年龄组 妊娠期高血压疾病 APELIN 

分 类 号：R714.246[医药卫生—妇产科学]