高原移居者红细胞滤过指数的变化及其机理  

CHANGES OF ERYTHROCYTE RHEOLOGY PROPERTIES IN IMMIGRANT SUBJECTS AT DIFFERENT AL-TITUDES AND ITS MECHANISM

作　　者：郗爱旗[1] 

机构地区：[1]青海省人民医院老年病研究室,西宁810007

出　　处：《中国应用生理学杂志》2001年第1期51-54,共4页Chinese Journal of Applied Physiology

基　　金：青海省科委资助课题

摘　　要：探讨不同海拔和同一海拔高度低氧环境不同血色素范围对高原健康人红细胞流变学特性的影响及其可能发生的机制。方法 :检测不同海拔高度 (2 2 6 0m、3 30 0m、40 80m)对 32 0健康人EFI、SOD和MDA的影响。结果 :随海拔高度的升高 ,高原健康人EFI和MDA含量明显升高 ,而红细胞SOD活性明显降低 ;EFI与MDA呈正相关 ,而与红细胞SOD活性呈负相关。同一海拔低氧环境Hb增高者 ,EFI和MDA升高 ,而红细胞SOD活性降低 ;随海拔升高 ,EFI和MDA含量明显升高 ,而红细胞SOD活性明显降低。结论 :不同海拔红细胞流变学和氧自由基代谢差异性的形成 ,低氧环境起核心作用 ;Aim: To explore the influence of altitude changes on red blood cell rheology properties and negative effects caused by it and possible mechanism. Methods: Erythrocyte filtration index (EFI), superoxide dismutase (SOD) and Malondialdehyde (MDA) were detected the mechanisms in which EFI changes. Results: EFI increased with increasing altitudes and there was a significant different in EFI at the different range of Hb at the same altitude and a significant different in EFI at the similar range of Hb at different altitudes. Correltive analyses showed that EFI was in a negative correlation with SOD activities, relations between EFI and MDA were on the contraty. Conclusion: Changes of SOD and MDA with increasing altitudes lead to abnormalities of erythrocyte rheology properties in healthy subjects.

关 键 词：高原健康人 海拔 氧自由基代谢 红细胞流变学 红细胞 滤过指数 

分 类 号：R331.141[医药卫生—人体生理学] R594.3[医药卫生—基础医学]