O/W型微乳对木犀草素增溶作用的研究  

Study on effect of O /W microemulsion in enhancing solubility of luteolin

作　　者：赵惠茹[1] 赵阳[1] 

机构地区：[1]西安医学院药学院,陕西西安710021

出　　处：《应用化工》2014年第6期1054-1056,1077,共4页Applied Chemical Industry

基　　金：陕西省教育厅科研计划项目(12JK1024)

摘　　要：采用伪三元相图制备了肉豆蔻酸异丙酯-聚氧乙烯氢化蓖麻油-无水乙醇-水的微乳体系,用紫外分光光度法测定了在微乳体系和水中木犀草素的溶解度,探讨O/W型微乳对木犀草素的增溶作用。研究表明,木犀草素在微乳中的溶解度是水中的561倍,微乳对木犀草素有明显的增溶作用。Preparing isopropyl myristate-cremophor RH-40-alchohol-water microemulsion system by using pseudoternary phase diagram,the solubilities of luteolin in microemulsion system and in water were determined by ultraviolet spectrophotometric method,the effect of O /W microemulsion in enhancing solubility of luteolin was investigated. The studies showed that the solubility of luteolin in microemulsion system was561 times as high as in water,the effect of microemulsion in enhancing solubility of luteolin is significant.

关 键 词：木犀草素 微乳 增溶 

分 类 号：TQ460.6[化学工程—制药化工] R944[医药卫生—药剂学]