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作 者:靳晓丽[1] 杨永康[2] 尤天庚[2] 赵中辛[2]
机构地区:[1]同济大学医学院,上海200120 [2]上海市同济大学附属东方医院胃肠外科
出 处:《中华普通外科学文献(电子版)》2014年第3期63-64,共2页Chinese Archives of General Surgery(Electronic Edition)
摘 要:患者女,18岁。因“反复进食后呕吐,伴消瘦2年余”入院胃肠内科。入院半年前曾因出现中上腹胀痛多次于外地医院就诊,胃镜检查结果仅提示胃窦炎伴胃黏膜糜烂,予以促消化治疗后症状无明显改善。月经史:14岁初潮,每次5-6d,量可,无痛经,3年前闭经。查体示体型消瘦,BMI为13.1kg/m^2,右上腹部轻压痛,墨菲氏征可疑阳性,振水音(+),其余体征阴性。Objective A meta analysis was conducted to examine the association between the dietary intake of n-3 fatty acids and colorectal cancer risk. Methods Articles published from Jan 1995 to May 2013 were identified through PubMed, EMBASE, CNKI and Cochrane Library database, and relevant references of the included studies were also retrieved. Two authors independently reviewed articles, extracted data and assessed the methodological quality. Meta-analyses were conducted by using STATA 11.0 software. Results A total of 7 case-control studies and 4 prospective cohort studies involving 253 479 participants were included. The pooled relative risks for the highest compared with the lowest n-3 fatty acids dietary intake were 0.88(95 % CI: 0.68-1.13; P=0.316, quartiles of intake, 6 studies) and 1.03(95% CI: 0.92-1.16; P=0.606, quintile of intake, 5 studies) for colorectal cancer risk. Conclusions There is insufficient evidence to suggest a significant association between dietary intake of n-3 fatty acids and colorectal cancer incidence. The effect of dietary supplementation with n-3 fatty on colorectal cancer risk needs further investigation.
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