硝苯地平缓释片、马来酸依那普利片和富马酸比索洛尔片对Ⅰ级高血压患者24h血压的影响  

Clinical effects of nifedipine sustained-release tablets, enalapril maleate tablets and bisoprolol fumarate tablets on 24-hour blood pressure in patients with Ⅰgrade hypertension

作　　者：邹仁民[1] 刘国树[2] 徐福山[1] 刘凤梅[1] 李冬云[2] 王亮[2] 张锦佳[2] 

机构地区：[1]北京军区总医院京西医院内科,北京100144 [2]解放军总医院,北京100853

出　　处：《中国药物应用与监测》2014年第3期131-133,179,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:比较国产硝苯地平缓释片、马来酸依那普利片和富马酸比索洛尔片对Ⅰ级高血压患者的降压效果。方法:182例患者随机分为3组:硝苯地平缓释片组(20 mg,62例)、依那普利组(5 mg,60例)与比索洛尔组(5 mg,60例),经过2周安慰剂导入期进入临床观察阶段,观察期4周。每组药物均为每日一次服用,并进行24 h动态心电、动态血压同时监测。结果:3种药物均能显著降低血压,硝苯地平缓释片、依那普利和比索洛尔组与治疗前相比,分别降低了(10±13)mm Hg,(19±11)mm Hg和(7±18)mm Hg;比索洛尔组降低24 h平均收缩压及白天平均舒张压的幅度大于硝苯地平缓释片组和依那普利组。结论:3种降压药每日一次服用,对Ⅰ级高血压患者均有明显降压疗效,且比索洛尔组疗效优于硝苯地平缓释片组及依那普利组。Objective： To observe the hypotensive effects of nifedipine sustained-release tablets, enalapril maleate tablets and bisoprolol fumarate tablets in patients withⅠgrade hypertension. Methods：A total of 182 patients withⅠgrade hypertension were randomly divided into three groups： nifedipine group （62 patients taking nifedipine sustained-release tablets 20 mg daily）, enalapril group （60 patients taking enalapril 5 mg daily） and bisoprolol group （60 patients taking bisoprolol 5 mg daily）. All patients entered 4-week clinical observation with 24-hour Holter and ambulatory blood pressure monitoring after 2-week placebo induce. Results：The three drugs signiifcantly reduced casual blood pressures. After administration the blood pressure of nifedipine group, enalapril group and bisoprolol group reduced （10 ± 13） mm Hg, （19 ± 11） mm Hg and （7 ± 18） mm Hg respectively. Bisoprolol showed more hypotensive effect on 24-hour mean systolic blood pressure and daytime mean diastolic blood pressure than nifedipine and enalapril. Conclusion：Administration of nifedipine sustained-release tablets 20 mg daily, enalapril 5 mg daily and bisoprolol 5 mg daily showed signiifcant hypotensive effect. Bisoprolol was better than nifedipine and enalapril.

关 键 词：高血压 动态血压 监测 硝苯地平 依那普利 比索洛尔 

分 类 号：R544.1[医药卫生—心血管疾病]