鲍曼不动杆菌耐药机制文献计量分析  

Bibliometric analysis of research papers about the resistance mechanisms of Acinetobacter baumannii

作　　者：刘斌[1,2] 马玲梅 梁蓓蓓[3] 王睿[3] 刘又宁[1] 

机构地区：[1]解放军总医院呼吸科,北京100853 [2]武警后勤学院附属医院呼吸与危重症医学科,天津300162 [3]解放军总医院药物临床研究中心,北京100853

出　　处：《中国药物应用与监测》2014年第3期186-189,共4页Chinese Journal of Drug Application and Monitoring

基　　金：国家科技部十二五重大专项滚动课题项目(2012ZX09303004-002)

摘　　要：目的:利用文献计量学的方法对鲍曼不动杆菌(Ab)耐药机制的相关文献进行统计分析,以便指导临床合理用药。方法:检索PubMed、Embase、SCI英文数据库,对鲍曼不动杆菌耐药机制的相关文献进行汇总,对纳入研究的文献年份分布、作者、语种、文章类型、药物类型等进行统计分析。结果:纳入研究的文献共计2061篇,文献数量呈逐年递增趋势。其中,研究最多的药物是亚胺培南;对于碳青霉烯类抗菌药物的耐药机制研究较多。关于耐药机制的研究,分别从基因或者蛋白等角度进行阐明。从文献发表期刊分析,微生物和抗感染领域对Ab耐药机制的关注度最高,其次为药理、药学领域。结论:碳青霉烯类耐药仍是鲍曼不动杆菌耐药研究领域的重点之一,其主要的耐药机制是产生水解碳青霉烯的β-内酰胺酶—OXA酶和金属β-内酰胺酶(MBL)。To investigate resistance mechanisms of Acinetobacter baumannii by bibliometric method. Methods： All literatures searched in PubMed, Embase and SCI database with the key words of.4cinetobacter baumannii, drug resistance were collected. The amount of literatures, publication date, authors, languages, types of papers and antibiotic were analyzed. Results： A total of 2061 literature papers were searched from three databases. The amount of literatures increased year by year. Imipenem was the most studied antibiotic. The most researches on resistance mechanisms of Acinetobacter baumannii focused on that of carbapenem drugs, which were clarified from the perspective of genes or proteins. Resistance mechanisms were mainly studied in the field of microbiology and anti-infection. Conclusion： Carbapenem resistance was always one focus of the drug resistance of Acinetobacter baumannii. The most prevalent mechanism of carbapenem resistance in Aeinetobacter baumannii is enzymatic degradation for carbapenemases, namely OXA type and metallo-β-lactamases （MBL）.

关 键 词：鲍曼不动杆菌 多重耐药 文献研究 计量分析 

分 类 号：R446.5[医药卫生—诊断学]