ICU鲍曼不动杆菌耐药性的分析  

Drug resistance of Acinetobacter baumanii strains isolated from intensive care unit

作　　者：李爱芳[1] 李国雄[1] 陈丽珠[1] 黄金伟[1] 丁卉[1] 丁茂文[1] 

机构地区：[1]丽水市中心医院微生物室,323000

出　　处：《浙江医学》2014年第9期788-790,共3页Zhejiang Medical Journal

摘　　要：目的了解ICU鲍曼不动杆菌的标本来源和抗生素耐药性,为合理应用抗生素和预防控制医院感染提供参考依据。方法对临床标本进行检测,共分离163株鲍曼不动杆菌,采用Vitek2-Compact进行鉴定,纸片扩散法(K-B法)进行药敏试验和WHONET5,4软件进行数据统计分析。结果从痰液标本中分离出143株,占87.73%,其次为尿液,占5.52%;对哌拉西林、头孢他啶、复方新诺明、头孢吡肟、环丙沙星、哌拉西林/他唑巴坦、左氧氟沙星、替卡西林/克拉维酸、美罗培南、亚胺培南耐药率分别为93.25%、93.25%、92.64%、92.64%、92.02%、92.02%、92.02%、92.02%、89 57%、89.57%;头孢哌酮/舒巴坦、多黏菌素B耐药率相对较低,分别为17.18%和0。结论鲍曼不动杆菌的耐药率处于高位,必须加强耐药性监测,为临床提供最新的耐药性资料,临床医师应合理选用抗生素,减少耐药菌株的产生。Objective To determine the antibiotic resistance of clinical isolates of Acinetobacter baumani from intensive care unit （ICU）. Methods One hundred and sixty three strains of Acinetobacter baumani were isolated from clinical samples of ICU patients. The isolates were identified by Vitek2- Compact bacterial identification analyzers （Biomerieux）. Disk diffusion test （Kirby- Bauer method） was used to determine the antibiotic susceptibility as recommended by CLIS 2012, the changes of antibi-otic resistance were analyzed by WHONET5.4 software. Results There were 143 strains isolated from the sputum specimens （87.73%）, followed by urine specimens （5.52%）. The resistances to Piperacil in, Ceftazidine, Cefepime, SMZ- TMP, Ciprofloxacin, Piperacil in/tazobactam, levofioxacin, Ticarcil in/clavulanic acid, Imipenem and Meropenem were 93.25%, 93.25%, 92.64%, 92.64%, 92.02%, 92.02%, 92.02%, 92.02%, 89.57% and 89.57%, respectively. The resistance to Cefeperazone/sulbacta and polymyxin B were only 17.18% and 0.0%, respectively. Conclusion The drug resistance rate of clinical isolates Acinetobacter baumani is high in ICU patients.

关 键 词：鲍曼不动杆菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]